性别:女
个人主页://labrjmart.cn/10641/68DA7E43E8F7F93D
职称: 副教授
电子邮件:[email protected]
导师类型: 博士生导师
学历:博士研究生
学科方向
071010-生物化学与分子生物学
0860-生物与医药
研究方向
在松阳洲教授统一部署下，本小组由副教授黄燕负责日常指导，利用肿瘤细胞、干细胞、免疫细胞和小鼠模型，探究细胞衰老和端粒的精准调控，致力于发现新的衰老通路交互作用和干预手段。欢迎本校本科生联系做毕设和科研项目，2024年招收中大专硕1名（考研）。
个人经历
2019.1-至今 中山大学副教授
2012.8-2018.12 中山大学“百人计划” 引进人才，讲师
2006.9-2012.6 中科院上海生科院生物化学与细胞生物学研究所，推免硕博
2002.9-2006.6 南京大学生物技术系， 本科
讲授课程
“生物医学基础”、“遗传学”、“遗传学实验”（原国家精品课程）、暑期小学期实验技能课“哺乳动物的基因克隆”、通识核心课“私人定制细胞治疗”、研究生课程“学术规范与论文写作”。获2017年全国高校生物学微课比赛二等奖；2018年广东省教学成果 二等奖（参与）；中大第8届教学成果奖 一等奖（参与）。参与撰写清华大学陈晔光院士主编《分子细胞生物学》教材第三版新章节“细胞衰老”，参与贺竹梅教授《生命伦理学》慕课建设。现和张雁教授合作讲授并进行“生物医学基础”知识图谱建设。
学术成就
2012年报道转录中介体复合物偶联RNA加工的新功能（Mol Cell封面），获中科院院长优秀奖、优秀博士论文奖，强生亚洲优秀论文一等奖。近年来聚焦细胞衰老的分子机制、端粒酶和端粒在生理和病理条件下的精准调控：鉴定出识别并防止端粒RNA:DNA杂交链过度形成的新蛋白ILF3（Protein Cell，in press）；发现Tin2通过抑制不依赖于端粒酶的端粒延伸以对抗染色质不稳定从而调控胚胎干细胞分化的功能（Stem Cell Report，2022）；筛选鉴定了来源于中药博落回的小分子SC通过靶向TERT转录和端粒酶组装的双重机制诱导广谱的肿瘤细胞衰老（Cells，2022）；鉴定出衰老新的标志物miR-185（Aging, 2020）；揭示了核酸外切酶TOE1参与端粒酶RNA亚基转录后加工从而调控端粒稳态（Nucleic Acids Res., 2019），利用涡虫研究端粒稳态维持和个体再生的机制（Sci Rep., 2016）；发现非经典转录因子Ccndbp1通过结合MyoD促进骨骼肌分化（J Cell Sci., 2016）；甘油激酶类Gykl1/Gk2通过调控线粒体聚集调控精子发生（Cell Dis., 2017）。第一或通讯作者SCI论文16篇，平均IF>7，总引用超400次。主持国家自然科学基金4项，广东省项目2项，获17年广州市珠江科技新星，17年全国高校生命科学微课比赛二等奖，授权2项专利。
承担课题
国家自然科学基金（面上），52万元，2023.1-2026.12
国家自然科学基金（面上），56万元，2021.1-2024.12
国家自然科学基金（面上），56万元，2019.1-2022.12（已结题）
国家自然科学基金（青年），26万元，2015.1-2017.12（已结题）
广东省自然科学基金（面上），10万元，2019.10-2022.9（已结题）
广东省科技计划项目，30万元，2015.9-2018.8（已结题）
广州市科技计划，30万元，2017.5-2020.4（已结题）
论文专著
Chuanle Wang#, Yan Huang#, *, Yue Yang, Ruofei Li, Yingying Li, Hongxin Qiu, Jiali Wu, Guang Shi, Wenbin Ma, Zhou Songyang*. ILF3 safeguards telomeres from aberrant homologous recombination as a telomeric R-loop reader. Protein Cell, in press
Siyu Yan; Song Lin; Hongxin Qiu; Yan Huang*. Regulation of telomerase towards tumor therapy. Cell and bioscience, invited review
Shanshan Yin, Fangyingnan Zhang, Song Lin, Wei Chen, Kai Weng, Dan Liu, Chuanle Wang, Zibin He, Yuxi Chen, Wenbin Ma, Junjiu Huang, Yan Huang* and Zhou Songyang*. TIN2 deficiency leads to ALT-associated phenotypes and differentiation defects in embryonic stem cells. Stem Cell Reports, 2022 May 10; 17:1183-1197.
Siyu Yan, Song Lin, Kexin Chen, Shanshan Yin, Haoyue Peng, Nanshuo Cai, Wenbin Ma, Zhou Songyang and Yan Huang*. Natural Product Library Screens Identify Sanguinarine Chloride as a Potent Inhibitor of Telomerase Expression and Activity. Cells, 2022 Apr 28;11:1485.
Nanshuo Cai#, Yifan Wu# and Yan Huang*. Induction of Accelerated Aging in a Mouse Model. Cells, 2022 Apr 22; 11:1418.
Chuanle Wang, Zhou Songyang and Yan Huang*. TRIM28 inhibits alternative lengthening of telomere phenotypes by protecting SETDB1 from degradation. Cell and Bioscience, 2021 Jul 30;11(1):149.
Tingting Li, Zhenhua Luo, Song Lin, Chujun Li, Shenkun Dai, Haoli Wang, Junjiu Huang, Wenbin Ma*, Zhou Songyang*, Yan Huang*. MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence. Aging (Albany NY), 2020,Jul 18;12(14):14791-14807.
Tingting Deng#, Yan Huang #,*, Kai Weng, Song Lin, Yujing Li, Guang Shi, Yali Chen, Junjiu Huang, Dan Liu, Wenbin Ma* and Zhou Songyang*. TOE1 Acts as a 3’ Exonuclease For Telomerase RNA and Regulates Telomere Maintenance. Nucleic Acids Research, 2019 Jan 10, DOI: 10.1093/nar/gky1019
Zhen Zhang, Hongwei Sun, Yu Chen, Tianqi Cao, Zhou Songyang, Junjiu Huang, Yan Huang*. Analysis of hpf1 expression and function in early embryonic development of zebrafish. Development Genes and Evolution, 2018 Mar 17, 228:141-147.
Yuxi Chen#, Puping Liang#, Yan Huang#, Minyan Li, Xiya Zhang, Chenhui Ding, Junyan Feng, Zhen Zhang, Xueqing Zhang, Yuanzhu Gao, Qinfeng Zhang, Shanbo Cao, Haiyan Zheng, Dan Liu, Zhou Songyang*, Junjiu Huang*. Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility. Cell Discovery, 2017 Aug 22, 3, 17030; doi:10.1038/celldisc.2017.30
Shanshan Yin#, Yan Huang#, *, Yingnan Zhangfang, Qiaoqin Zhong, Pengqing Li, Junjiu Huang, Dan Liu and Zhou Songyang. SmedOB1 is Required for Planarian Homeostasis and Regeneration, Scientific Reports, | 2016 6:34013 | DOI: 10.1038/srep34013.
Yan Huang#, Bohong Chen#, Miaoman Ye, Puping Liang, Yingnan Zhangfang, Junjiu Huang, Mingyao Liu, Zhou Songyang and Wenbin Ma*, Ccndbp1 is a new positive regulator of skeletal myogenesis, Journal of Cell Science, 2016 Jul 15, 129(14): 2767-2777 （获发育生物学权威杂志Development转载推荐）
Yan Huang#, Yuanyan Xiong#, Zhuoheng Lin, Xuyang Feng, Xue Jiang, Zhou Songyang, Junjiu Huang*, Specific Tandem 3'UTR Patterns and Gene Expression Profiles in Mouse Thy1+ Germline Stem Cells, PLoS One, 2015 Dec 29, 10(12): e0145417
Yan Huang, Xiao Yao and Gang Wang*, 'Mediator-ing' messenger RNA processing, Wiley Interdiscip Rev RNA, 2015 Mar-Apr, 6(2): 257-269
Yan Huang, Puping Liang, Dan Liu, Junjiu Huang, Zhou Songyang*, Telomere regulation in pluripotent stem cells,Protein Cell, 2014 Mar, 5(3): 194-202
Yan Huang, Wencheng Li, Xiao Yao, Qi-jiang Lin, Jing-wen Yin, Yan Liang, Monika Heiner, Bin Tian, Jingyi Hui and Gang Wang*, Mediator Complex Regulates Alternative mRNA Processing via the MED23 Subunit, Molecular Cell, 2012 Feb 24, 45(4): 459-469 (封面文章，被Faculty of 1000推荐)
Wei Wang, Xiao Yao, Yan Huang, Xiangming Hu, Runzhong Liu, Dongming Hou, Ruichuan Chen and Gang Wang*, Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb, Transcription, 2013 Jan 1; 4(1): 39–51
Wei Chen, Wenshu Zeng, Xiaodi Li, Weiliang Xiong, Mengdie Zhang, Yan Huang, Longshu Zhou* and Songshan Jiang*, MicroRNA-509-3p increases the sensitivity of epithelial ovarian cancer cells to cisplatin-induced apoptosis,Pharmacogenomics, 2016 Feb, 17(3): 187-97.
Jing-wen Yin, Yan Liang, Ji Yeon Park, Dongrui Chen, Xiao Yao, Qi Xiao, Zhen Liu, Bo Jiang, Yu Fu, Menghan Bao, Yan Huang, Yuting Liu, Jun Yan, Min-sheng Zhu, Zhongzhou Yang, Pingjin Gao, Bin Tian, Dangsheng Li, and Gang Wang, Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation, Genes Dev, 2012 Oct 1, 26(19): 2192-2205
Wei Wang, Lu Huang, Yan Huang, Jing-wen Yin, Arnold J. Berk, Jeffrey M. Friedman and Gang Wang1* Mediator MED23 links insulin signaling to the adipogenesis transcription cascade, Developmental Cell, 2009 May 19, 16(5):764–771
Guo Chen, Dong-Ping Wei, Li-Jun Jia, Bo Tang, Luan Shu, Kui Zhang, Yun Xu, Jing Gao, Xiao-Feng Huang, Wen-Hui Jiang, Qin-Gang Hu, Yan Huang, Qiang Wu, Zhi-Hua Sun, Jian-Fa Zhang and Zi-Chun Hua, Oral delivery of tumor-targeting Salmonella exhibits promising therapeutic efficacy and low toxicity, Cancer Science, 2009 Dec, 100(12): 2437–2443
Li-Jun Jia, Dong-Ping Wei, Qi-Ming Sun, Yan Huang, Qiang Wu and Zi-Chun Hua, Oral delivery of tumor-targeting Salmonella for cancer therapy in murine tumor models, Cancer Science, 2007 July, 98(7): 1107–1112
Li-Jun Jia, Dong-Ping Wei, Qi-Ming Sun, Guang-Hui Jin, Shu-Feng Li, Yan Huang and Zi-Chun Hua*, Tumor-targeting Salmonella typhimurium improves cyclophosphamide chemotherapy at maximum tolerated dose and low-dose metronomic regimens in a murine melanoma model, Int. J. Cancer, 2007 Aug 1, 121(3): 666–674
王传乐，黄燕*，松阳洲*，端粒功能障碍综合征的研究进展，中国基础科学，2021，23(06)
黄燕（通讯作者），黄军就，小学期实验技能课整合毕业设计促进生命科学本科培养的改革初探，高校生物学教学研究（电子版），2017年3月，7（1）：49-53
钱程，黄燕（通讯作者），从管理学角度论细胞治疗，环球市场信息导报，2016年6月
山中申弥，黄燕，特定因子诱导多能干细胞，生命科学，2010年第三期（2009年国际生化大会编译）
