性别: 女
电子邮件: [email protected]
导师类型: 博士生导师
工作电话: 39332848
职称: 教授
学科方向:
071009-细胞生物学
071010-生物化学与分了生物学
0710Z1-生物信息学
0860-生物与医药
研究方向
免疫细胞信号转导，免疫应答
个人经历
1987年和1990年分别获华东师范大学理学学士和硕士学位，1995年于中山大学获理学博士学位并留校工作。1997年底至2004年，先后于美国Scripps研究所（The Scripps Research Institute）及 美国拉荷亚过敏与免疫研究所（La Jolla Institute for Allergy and Immunology）从事博士后研究员工作（Postdoc Fellow, Senior Scientist）。2005年回国后，主要开展T细胞受体信号通路及T细胞免疫相关研究，曾入选教育部“新世纪优秀人才支持计划”。先后主持多项国家自然科学基金面上项目和科技部国家重点基础研究发展计划(973计划) 的研究课题等。主要研究方向，SUMO化蛋白修饰在T细胞受体近端信号中的调节功能及机制， p38IP蛋白对T细胞活化、发育与分化等的调节与机制。
讲授课程
免疫学I，II
学术成就
论文专著
He Y, Yang Z#, Zhao CS#, Xiao Z#, Gong Y, Li YY, Chen Y, Du Y, Feng D, Altman A, Li Y*. T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1. Elife. 2021 Jun 10;10:e67123. doi: 10.7554/eLife.67123
Zhou J#, Xiao Z#, Zhan Y, Qu X, Mou S, Deng C, Zhang T, Lan X, Huang S, Li Y*. Identification and Characterization of the Amphioxus Lck and Its Associated Tyrosine Phosphorylation-Dependent Inhibitory LRR Receptor. Front Immunol. 2021 Jun 3;12:656366. doi: 10.3389/fimmu.2021.656366.
Wang XD#, Zhao CS#, Wang QL, Zeng Q, Feng XZ, Li L, Chen ZL, Gong Y, Han J, Li Y*. The p38-interacting protein p38IP suppresses TCR and LPS signaling by targeting TAK1. EMBO Rep. 2020 Jul 3;21(7):e48035. doi: 10.15252/ embr.201948035.
Wang QL#, Liang JQ#, Gong BN, Xie JJ, Yi YT, Lan X, Li Y*. T Cell Receptor (TCR)-Induced PLC-γ1 Sumoylation via PIASxβ and PIAS3 SUMO E3 Ligases Regulates the Microcluster Assembly and Physiological Function of PLC-γ1. Front Immunol. 2019 Feb 28;10:314.
Xie J, Han X, Zhao C, Canonigo-Balancio AJ, Yates JR 3rd, Li Y, Lillemeier BF, Altman A*. Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling. Sci Signal. 2019 Apr 16;12(577)
Chen ZL, Gong BN, Wang QL, Xiao ZH, Deng C, Wang WQ, Li Y*. Characterisation of amphioxus protein kinase C-δ/θ reveals a unique proto-V3 domain suggesting an evolutionary mechanism for PKC-θ unique V3. Fish Shellfish Immunol. 2018 Nov 5, Doi:10.1016/j.fsi.2018.11.001
Qu X, Lan X, Deng C, Zhou J, Du J, Huang S, Li Y*. Molecular mechanisms underlying the evolution of the slp76 signalosome. Sci Rep. 2017 May 4;7(1):1509
Yu X, Wang QL, Li YF, Wang XD, Xu A*, Li Y*. A novel miR-200b-3p/p38IP pair regulates monocyte/macrophage differentiation. Cell Discov. 2016 Jan 26;2:15043.
Wang XD#, Gong Y#, Chen ZL#, Gong BN#, Xie JJ, Zhong CQ, Wang QL, Diao LH, Xu A, Han J, Altman A, Li Y*. TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation. Nat Immunol. 2015 Nov;16(11):1195-203.
Liu X, Xiao W, Wang XD, Li YF, Han J, Li Y*. The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5. J Biol Chem. 2013 Dec 20;288(51):36648-61.
Xie JJ, Liang JQ, Diao LH, Altman A, Li Y*. TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter. J Immunol. 2013 Apr 15;190(8):4027-36.
Wang K, Diao LH, Gong Y, Liu X, Li Y*. NEMO differentially regulates TCR and TNF-α induced NF-κB pathways and has an inhibitory role in TCR-induced NF-κB activation. Cell Signal. 2012 Aug;24(8):1556-64.
Zohn IE, Li Y, Skolnik EY, Anderson KV, Han J, Niswander L. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell. 2006 Jun 2;125(5):957-69.
Li Y, Sedwick CE, Hu J, Altman A. Role for protein kinase Ctheta (PKCtheta) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-kappaB activation. J Biol Chem. 2005 Jan 14;280(2):1217-23.
Li Y, Hu J, Vita R, Sun B, Tabata H, Altman A. SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway. EMBO J. 2004 Mar 10;23(5):1112-22.
Li Y, Jiang B, Ensign WY, Vogt PK, Han J. Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase. Cell Signal. 2000 Dec;12(11-12):751-7.
