性别:女
职称:教授
学历:博士研究生
电子邮件: [email protected]
导师类型: 博士生导师
学科方向:071003-生理学
研究方向
动物生殖生理学 与 发育生物学
个人经历
教育经历：
1991.09-1996.07 中山大学生物系动物学专业，理学博士
1987.09-1991.07 中山大学生物系动物学专业，理学学士
工作经历：
2019.03-今 赌博app-网络赌博软件
动物学教研室 主任
2013.10-2015.12 中山大学教务处副处长（兼职）
2011.01-今 赌博app-网络赌博软件
教授
2001.06-2010.12 赌博app-网络赌博软件
副教授
1999.09-2001.06 赌博app-网络赌博软件
讲师
1997.06-1999.08 美国康乃狄格大学生理和神经生物学系 博士后
讲授课程
主讲本科专业基础课《组织学与胚胎学》、《生理学》、《发育生物学实验》和《现代生物学实验技术》等，核心通识课《现代生命科学导论》和《生命科学导论实验》、及研究生课程《细胞及发育生物学》。
学术成就
多年从事生殖生物学和分子内分泌学研究，先后主持国家自然科学基金和广东省自然科学基金等7项研究课题，对黄鳝促性腺激素释放激素（GnRH）、促性腺激素（GtH）和芳香化酶（Cyp19）等生殖相关功能基因和受体的结构、功能和表达调节进行了较深入的研究，发表学术论文50余篇，其中SCI论文40余篇。
承担课题
1.国家重点研发计划：水产养殖生物性别转换与环境因子的互作机制，102.4万，2018.12-2022.12，研究骨干。
2.国家自然科学基金项目：硬骨鱼类黄鳝腺垂体中雌激素膜受体和核受体信号通路及其功能分析，65万，2016.01-2019.12，主持。
3.国家自然科学基金（31172088），硬骨鱼类黄鳝卵巢早期分化发育及其分子机制分析，63万，2012.01-2015.12，主持。
4.国家自然科学基金（30970359），硬骨鱼类黄鳝垂体中cyp19基因表达调控及其功能分析，31万，2010.01-2012.12，主持。
5.国家自然科学基金（30570228），黄鳝三种促性腺激素释放激素系统的表达特征及其功能研究，25万，2006.01-2008.12，主持。
6.国家自然科学基金（30170130），黄鳝促性腺激素释放激素的cDNA克隆和功能研究，18万，2002.01-2004.12，主持。
论文专著
1. Feiyan Meng, Lihong Zhang*, Weimin Zhang*. Two forms of G protein- coupled estrogen receptor 1 in the ricefield eel: Expression and functional characterization in relation to ovarian follicle development. General and Comparative Endocrinology. 2021, 304:113720.
2. Yunfeng Nin, Miao Fan, Qiongyou Liu, Huijie Lu, Shangyong Qian, Xin Cui, Feiyan Meng, Xi Li, Xing Xu, Shu Sun, Youwei Zhang, Lihong Zhang*, Weimin Zhang*. Two Foxo1 homologues in the orangespotted grouper Epinephelus coioides: sequences, expression, and possible involvement in the activation of cyp19a1a expression in the ovary. Fish Physiol Biochem, 2021,47(5):1597-1610.
3. Tao Yan, Huijie Lu, Chao Sun, Yalian Peng, Feiyan Meng, Riping Gan, Xin Cui, Chengxiang Wu, Shen Zhang, Yumei Yang, Lihong Zhang*,Weimin Zhang*. Nr5a homologues in the ricefield eel Monopterus albus: Alternative splicing, tissue-specific expression, and differential roles on the activation of cyp19a1a promoter in vitro. General and Comparative Endocrinology. 2021, 312:113871.
4. Wei Yang, Ning Zhang, Yangsheng Wu, Lanxin Zhang, Lihong Zhang*, Weimin Zhang*. Oxytocin-like signal regulates Lh cells directly but not Fsh cells in the ricefifield eel Monopterus albus. Biology of Reproduction, 2020, 1–11.
5. Zhiqiang Zheng, Minqi Liu, Feiyan Meng, Weimin Zhang, Lihong Zhang*. Differential distribution and potential regulatory roles of estrogen receptor 2a and 2b in the pituitary of ricefield eel Monopterus albus. Gen Comp Endocrinol. 2020, 298:113554.
6. Boyang Shi, Huijie Lu, Lihong Zhang*, Weimin Zhang*. Nr5a1b promotes and Nr5a2 inhibits transcription of lhb in the orange-spotted grouper Epinephelus coioides. Biol Reprod. 2019, 101(4):800-812.
7. Boyang Shi, Huijie Lu, Lihong Zhang*, Weimin Zhang*. A homologue of Nr5a1 activates cyp19a1a transcription additively with Nr5a2 in ovarian follicular cells of the orange-spotted grouper. Mol Cell Endocrinol. 2018, 460:85-93.
8. Dong Chen, Wei Yang, Shiying Han, Huiyi Yang, Xin Cen, Jiang Liu, Lihong Zhang*, Weimin Zhang*. A Type IIb, but Not Type IIa, GnRH Receptor Mediates GnRH-Induced Release of Growth Hormone in the Ricefield Eel, Frontier in Endocrinology, 2018, 9:721.
9. Jinfeng Cai, Wei Yang, Dong Chen, Yize Zhang, Zhi He, Weimin Zhang, Lihong Zhang*; Transcriptomic analysis of the differentiating ovary of the protogynous ricefield eel Monopterus albus, BMC Genomics, 2017, 18(1):573.
10. Dong Chen, Jiang Liu, Wanping Chen, Shuxia Shi, Weimin Zhang*, Lihong Zhang* Expression and ontogeny of growth hormone (Gh) in the protogynous hermaphroditic ricefield eel (Monopterus albus), Fish Physiology and Biochemistry, 2015, 41(6): 1515~1525.
11. Zhi He, Yixue Li, Yangsheng Wu, Shuxia Shi, Chao Sun, Qingli Deng, Jun Xie, Taixing Wang, WeiminZhang,Lihong Zhang*. Differentiation and morphogenesis of the ovary and expression of gonadal development-related genes in the protogynous hermaphroditic ricefield eel Monopterus albus, Journal of Fish Biology, 2014, 85(5): 1381~1394.
12. Yang Zhang, Shen Zhang, Zhixin Liu, Lihong Zhang*, Weimin Zhang*. Epigenetic modifications during sex change repress gonadotropin stimulation of cyp19a1a in a teleost ricefield eel (Monopterus albus). Endocrinology, 2013, 154(8):2881-2890.
13. Yang Zhang, Shen Zhang, Wenliang Zhou, Xing Ye, Wei Ge, Christopher H.K. Cheng, Haoran Lin, Weimin Zhang*, Lihong Zhang*. Androgen rather than estrogen up-regulates brain-type cytochrome P450 aromatase (cyp19a1b) gene via tissue-specific promoters in the hermaphrodite teleost ricefield eel Monopterus albus, Molecular and Cellular Endocrinology, 2012, 350:125-135.
14. Yangsheng Wu, Zhi He, He Jiang, Lihong Zhang*, Weimin Zhang*. Ontogeny of immunoreactive Lh and Fsh cells in relation to early ovarian differentiation and development in protogynous hermaphroditic ricefield eel Monopterus albus. Biology of reproduction, 2012，86(3):93.
15. Lihong Zhang, Javier A. Tello, Weimin Zhang, Pei-San Tsai. Molecular Cloning, Expression Pattern, and Immunocytochemical Localization of a Gonadotropin- Releasing Hormone-like Molecule in the Gastropod Mollusk, Aplysia californica. General and Comparative Endocrinology. 2008,156(2):201-209．
16. Pei-San Tsai and Lihong Zhang. The Emergence and Loss of Gonadotropin- Releasing Hormone (GnRH) in Protostomes: Orthology, Phylogeny, Structure, and Function. Biology of Reproduction. 2008, 79:798–805.
17. Yang Zhang, Weimin Zhang, Huiyi Yang, Wenliang Zhou, Chaoqun Hu, Lihong Zhang*. Two Cytochrome P450 Aromatase Genes in the Hermaphrodite Ricefield Eel Monopterus albus: mRNA Expression during Ovarian Development and Sex Change. Journal of Endocrinology. 2008, 199:317-331.
