性别:男
工作电话:84113010
职称:副教授
学历: 博士
个人主页: //orcidorg/0000-0002
4709-1507
电子邮件:[email protected]
导师类型:博士生导师
学科方向:
071002-动物学
071005-微生物学
071009-细胞生物学
071010-生物化学与分子生物学
0860-生物与医药

 

研究方向

分子寄生虫学及进化

寄生虫是一类特殊的动物，需要寄生在一个或多个宿主体内。我们不仅研究寄生虫的形态、生活史、感染力、抗药性等基本寄生虫学特征，还研究基因及蛋白功能与进化。

招生专业：微生物学（硕士）/动物学（博士）/生物医药与健康（博士）

 

个人经历

2013 – 至今 副教授 博士生导师 中山大学
2018 – 2021 亚洲原生生物学家委员会秘书长 亚洲原生生物学家委员会
2014 – 至今 广东省动物学会理事-常务理事 广东省动物学会
2017 – 至今 原生动物学分会理事-副秘书长 中国动物学会
2018 – 至今 广东省寄生虫学会理事 广东省寄生虫学会
2010 – 2012 居里夫人访问学者 英国牛津大学
2011 – 2012 英国STEM大使 Researchers in Residence
2008 – 2010 博士后 捷克南波希米亚大学
2003 – 2008 博士 中山大学
1999 – 2003 学士 中山大学

 

 

 

 

 

 

 

 

 

 

讲授课程

滨海动物学实习（本科大一暑假）

生物化学（本科大二第一学期）

学术规范与论文写作（研究生第一年第二学期）

 

学术成就

一直从事人兽共患寄生虫的研究，并取得显著成绩，2005年迄今，在PNAS、the Lancet Infectious Diseases和Molecular Biology and Evolution等国际顶级学术期刊杂志发表论文多篇，SCI论文七十余篇，影响因子10及以上有十余篇，得到寄生生物领域国内外同行认可。

研究成果加深了学术界对寄生生物的生物学特性在细胞，蛋白及分子水平上的认识，在物种形成及进化等宏观方面做出了积极贡献，也为寄生虫的控制及药物靶点设计提供了重要的理论基础。
 

获广东省杰青项目、欧盟居里夫人基金访问学者项目、瑞典国际科学基金青年项目、广州市珠江新星等人才计划资助。

 

承担课题

主持的科研基金:

2023  –  2026       国家自然科学基金面上项目(32270446) 
布氏锥虫基体蛋白BBLP调节基体组装的分子机制

2022  –  2024       广州市基础研究计划基础与应用基础研究项目（涉农项目）(202201011831) 
草鱼华支睾吸虫（肝吸虫）感染防控关键技术研究

2022  –  2024       广东省自然科学基金面上项目(2022A1515011874) 
利用锥虫模型研究中心体关键蛋白的功能

2018  –  2021      国家自然科学基金面上项目(31772445)
利用iNOS基因敲除大鼠研究宿主NO对弓形虫增殖与分化的调控

2016  –  2020      广东省自然科学基金杰出青年项目(2016A030306048)
人畜共患病原体锥虫的遗传特性及分化调控

2015  –  2018      广州市珠江科技新星专项项目(201506010011)
人畜共患锥虫的遗传特性及分化调控

2015  –  2018      广东省自然科学基金面上项目(2014A030313164)
利用布氏锥虫BBCP 蛋白研究真核生物中心体的蛋白组成及蛋白功能

2015  –  2017      国家自然科学基金青年项目(31402029)
利用布氏锥虫BBCP 蛋白研究真核生物中心体的蛋白组成及蛋白功能

参加的科研基金:

2018 –  2022      国家自然科学基金重点国际合作项目(31720103918) PAG基因家族功能及其在锥虫分化中的作用

2017  –  2021      国家重点研发计划畜禽重大疫病防控与高效安全养殖综合技术研发(2017YFD0500400)畜禽重要胞内寄生原虫的寄生与免疫机制研究1856万

2016  –  2018      国家重点研发计划生物安全关键技术专项(2016YFC1200500)重要热带病传播相关的入侵媒介生物及其病原体的生物学特性研究1277万

2015  –  2018      广东省自然科学基金重点项目(2015A030311042)
布氏锥虫分化机理的分子基础

 

论文专著

  1. Zhixun Li, Wenjing Du, Jiong Yang, De-Hua Lai, Zhao-Rong Lun, Qiang Guo. (2023) Cryo-electron tomography of Toxoplasma gondiiindicates that the conoid fiber may be derived from microtubules. Advanced Sciences. 2206595.
  2. Wan W#, Dong H#, Lai DH#, Yang J, He K, Tang X, Liu Q, Hide G, Zhu XQ, Sibley LD, Lun ZR, Long S*. (2023) The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments. Nat Commun 14:977. doi:10.1038/s41467-023-36571-4
  3. Wen YZ, Tang HT, Cai XL, Wu N, Xu JZ, Su BX, Hide G, Lun ZR, Lai DH* (2022) PAG3 promotes the differentiation of bloodstream forms inTrypanosoma brucei and reveals the evolutionary relationship among the Trypanozoon trypanosomes. Front. Cell. Infect. Microbiol.12:1021332. doi: 10.3389/fcimb.2022.1021332
  4. Zhang P, Chen K, Svobodová M, Yang TB, Lukeš J, Zhang JY, Lun ZR, Lai DH*. (2022) Does the fish-infecting Trypanosoma micropteri belong to Trypanosoma carassii? Folia Parasitologica. 69:024. doi: 10.14411/fp.2022.024
  5. Wang JF, Lin RH, Zhang X, Hide G, Lun ZR*, Lai DH*. (2022) Novel insertions in the mitochondrial maxicircle of Trypanosoma musculi, a mouse trypanosome. Parasitology. 149:1546–55. //doi.org/10.1017/S0031182022001019
  6. Chen K, Zhang P, Yang TB, Wen YZ, Hide G, Lun ZR*, Lai DH*. (2022) Nile tilapia (Oreochromis niloticus) can be experimentally infected with both marine and fresh water fish trypanosomes. Exp Parasitol. 239:108288.
  7. Su BX, Wang JF, Yang TB, Hide G, Lai DH*, Lun ZR*. (2022) A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis. Int J Parasitol 52:253–264. doi: 10.1016/j.ijpara.2021.10.009
  8. Cai X-L, Li S-J, Zhang P, Li Z, Hide G, Lai DH*, Lun ZR* (2022) The occurrence of malignancy in Trypanosoma brucei brucei by rapid passage in mice. Front. Microbiol. 12:806626. Doi: 10.3389/fmicb.2021.806626.
  9. Hu Z, Wu D, Lu J, Zhang Y, Yu S-M, Xie Y, Li H, Yang J, Lai D-H, Zeng K, Jiang H, Lun Z-R, Yu X. (2022) Inflammasome activation dampens type I IFN signaling to strengthen anti-Toxoplasma immunity. mBio, 13(6): e0236122. DOI:10.1128/mbio.02361-22.
  10. Shen J, Yu S, Peng M, Lai D-H, Hide G, Wu Z-D, Lun Z-R. (2022) iNOS is essential to maintain a protective Th1/Th2 response and the production of cytokines/chemokines against Schistosoma japonicum infection in rats. Plos Neglected Tropical Diseases, 16(5): e0010403. DOI:10.1371/journal.pntd.0010403.
  11. Fuchs AG, Soraires Santacruz MC, Fusco OA, Hoffer AM, Zhang C-X, Zhang F, Esteva MI, Rial MS, Fichera LE, Cid NG, Glisoni RJ, Lai D-H, Bontempi EJ.(2021) Trypanocidal effect of Diminazene aceturate by intranasal administration. Comparison among formulations. Int Jour HS [Internet]. 2021 Dec. 3;(1). Available from //ijhsc.com/journal/article/view/33
  12. Chen YF#, Liao L-F#, Wu N, Gao JM, Zhang P, Wen YZ, Hide G, Lai DH*, Lun ZR*. (2021) Species identification and phylogenetic analysis ofLeishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People’s Republic of China. PLoS Negl. Trop. Dis. 15(12): e0010055. (Onlined) Doi: 10.1371/journal.pntd.0010055
  13. Chen YF, Yu S, Wu C, Wu N, Shen J, Shen J, Gao JM, Wen YZ, Hide G, Lai DH*, Lun ZR*. (2021) Innate resistance to Leishmania amazonensisinfection in rat is dependent on NOS2. Front. Microbiol. 12:733286. doi: 10.3389/fmicb.2021.733286
  14. Wang ZJ, Yu SM, Gao JM, Zhang P, Hide G, Yamamoto M, Lai DH*, Lun ZR*. (2021) High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats. iScience. 24:103280. doi: 10.1016/j.isci.2021.103280
  15. Cai XL, Wang W, Lai DH, Zhang X, Yao J, Yu Y, Li S, Hide G, Bai H, Duan L*, Lun ZR* (2021) Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity. Acta Trop. 219: 105919.

  16. Qin A, Chen S, Wang P, Huang X, Zhang Y, Liang L, Du L-R, Lai D-H, Ding L, Yu X and Xiang AP (2021) Knockout of NOS2 promotes adipogenic differentiation of rat MSCs by enhancing activation of JAK/STAT3 signalling. Front. Cell Dev. Biol. 9:638518. doi: 10.3389/fcell.2021.638518

  17. Lai DH*, Moreira-Leite F, Xu ZS, Yang J, Gull K. (2021) A specific basal body linker protein provides the connection function for basal body inheritance in trypanosomes. Proc. Natl. Acad. Sci. USA. 118(8): e2014040118.

  18. Gao J-M, Yi S-Q, Geng G-Q, Xu ZS, Hide G, Lun ZR, Lai DH*. (2021) Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii. Parasitology 148:703–711. doi:10.1017/S0031182021000196

  19. Gao J-M, Qian Z-Y, Hide G, Lai D-H, Lun Z-R, Wu Z-D (2020). Human African trypanosomiasis: the current situation in endemic regions and the risks for nonendemic regions from imported cases. Parasitology 147: 922–931.

  20. Li SJ, Zhang X, Lukeš J, Li BQ, Wang JF, Qu LH, Hide G, Lai DH*, Lun ZR. (2020) Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi. Nucl. Acids Res. 48(17):9747–9761. 25 Sep, doi: 10.1093/nar/gkaa700

  21. Yang Y, Yu S-M, Chen K, Hide G, Lun Z-R*, Lai D-H*. (2020) Temperature is a key factor influencing the invasion and proliferation of Toxoplasma gondii in fish cells. Exp. Parasitol. 217:107966. Oct doi:10.1016/j.exppara.2020.107966

  22. Xu ZS, Li FH, Hide G, Lun ZR*, Lai DH*. (2020) Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei. Parasit. Vectors 13:214. doi:10.1186/s13071-020-04068-4 May

  23. Xiong J#, Chen JP#, Chen XG#,..., Lai DH#, et al. (2019) Progress of protozoological studies in China: Hot spots and new patterns (in Chinese).  Sci Sin Vitae. 49(10):1301–1322. doi:10.1360/SSV-2019-0127[熊杰#, 陈建平#, 陈晓光#,...赖德华#, 等. 进展中的原生动物学研究: 热点领域与新格局 (2019) 中国科学: 生命科学. 49(10):1301–1322]

  24. Abeywickrema M, Vachova H, Farr H, Mohr T, Wheeler RJ, Lai DH, Vaughan S, Gull K, Sunter JD, Varga V*. (2019) Non-equivalence in old- and new-flagellum daughter cells of a proliferative division in Trypanosoma brucei. Mol Microbiol. 112(3):1024–1040. 2019 Jul 8. doi: 10.1111/mmi.14345.

  25. Xu JB, Zhang YL, Huang J, Lu SJ, Sun Q, Chen PX, Jiang P, Qiu ZE, Jiang FN, Zhu YX, Lai DH, Zhong WD, Lun ZR, Zhou WL* (2019) Increased intracellular Cl- concentration mediates Trichomonas vaginalis-induced inflammation in the human vaginal epithelium. Int J Parasitol. 2019 Aug;49(9):697–704. doi: 10.1016/j.ijpara.2019.04.005.

  26. Gao JM#, He ZH#, Xie YT, Hide G, Lai DH*, Lun ZR* (2019) The association between Toxoplasma gondii infection and postpartum blues. J. Affect. Disorders 250:404–409.

  27. Zhang X, Li SJ, Li Z, He CY, Hide G, Lai DH*, Lun ZR* (2019) Cell cycle and cleavage events during in vitro cultivation of bloodstream forms of Trypanosoma lewisi, a zoonotic pathogen. Cell Cycle. 18(5):552–567. doi: 10.1080/15384101.2019.1577651

  28. Bando H, Sakaguchi N, Lee Y, Pradipta A, Ma JS, Tanaka S, Lai DH, Liu J, Lun Z-R, Nishikawa Y, Sasai M and Yamamoto M (2018) Toxoplasma effector TgIST targets host IDO1 to antagonize the IFN-g-induced anti-parasitic response in human cells. Front. Immunol. 9:207 doi: 10.3389/fimmu.2018.02073

  29. An R, Tang Y, Chen L, Cai H, Lai DH, Liu K, Wan L, Gong L, Yu L, Luo Q, Shen J, Lun ZR,  Ayala FJ, Du J. (2018) Encephalitis is mediated by ROP18 of Toxoplasma gondii, a severe pathogen in AIDS patients. Pro. Nat. Acad. Sci. USA. 115(23):E5344–E5352. doi: 10.1073/pnas.1801118115

  30. Zhang X, Hong XK, Li SJ, Lai DH, Hide G, Lun ZR, Wen YZ. (2018) The effect of normal human serum on the mouse trypanosome Trypanosoma musculi in vitro and in vivo. Exp. Parasitol. 184:115–120.

  31. Shen J#, Lai DH#, Wilson RA, Chen YF, Wang LF, Yu ZL, Li MY, He P, Hide G, Sun X, Yang TB, Wu ZD*, Ayala FJ*, Lun ZR*. (2017) Nitric oxide blocks the development of the human parasite Schistosoma japonicum. Proc. Natl. Acad. Sci. USA. 114 (38): 10214–10219. doi: 10.1073/pnas.1708578114. (影响因子: 9.6) 2017.9.5

  32. Hong XK, Zhang X, Fusco OA, Lan YG, Lun ZR, Lai DH*(通讯作者). (2017) PCR-based identification of Trypanosoma lewisi and Trypanosoma musculi using maxicircle kinetoplast DNA. Acta Tropica. 171:207–212. (影响因子: 2.4)

  33. Li K, Zhou S, Guo Q, Chen X, Lai DH, Lun ZR, Guo X. (2017) The eIF3 complex of Trypanosoma brucei: composition conservation does not imply the conservation of structural assembly and subunits function. RNA. 23(3):333–345. doi: 10.1261/rna.058651.116. Mar (影响因子: 3.7)

  34. Li Z, Guo Q, Zheng L, Ji Y, Xie YT, Lai DH, Lun ZR, Suo X, Gao N. (2017) Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii. Cell Res. doi: 10.1038/cr.2017.104. (影响因子: 7.3)

  35. Xie YT, Gao JM, Wu YP, Tang P, Hide G, Lai DH*(通讯作者), Lun ZR*. (2017) Recombinant α-actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis. Parasits Vectors. 10(1):83. doi: 10.1186/s13071-017-2009-8. 2017 Feb 16 (影响因子: 3.23)

  36. Gao JM, Xie YT, Xu ZS, Chen H, Hide G, Yang TB, Shen JL, Lai DH*(通讯作者), Lun ZR*.(2017) Genetic analyses of Chinese isolates of Toxoplasma gondii reveal a new genotype with high virulence to murine hosts. Vet. Parasitol.241:52–60. doi: 10.1016/j.vetpar.2017.05.007. 2017 Jul 15. (影响因子: 2.5)

  37. Qin A(共一), Lai DH(共一), Liu Q, Huang W, Wu Y, Chen X, Yan S, Xia H, Hide G, Lun ZR*, Ayala FJ*, Xiang* AP. (2017) Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against Toxoplasma gondii. Proc. Natl. Acad. Sci. USA.  114(6):1365–1370. (影响因子: 9.6) 2017.2.7

  38. Wen YZ, Su BX, Lyu SS, Hide G, Lun ZR, Lai DH*. (2016) Trehalose, an easy, safe and efficient cryoprotectant for the parasiticprotozoan Trypanosoma brucei. Acta Tropica 164,  297–302. (影响因子: 2.4) Dec

  39. 赖德华，吴娜，谢祎婷，洪晓昆，陈允甫，廖力夫，伦照荣*. (2016)一例输入性皮肤利什曼病病原体的鉴定. 中国寄生虫学与寄生虫病杂志34(3):295–296,封3. [Lai DH, Wu N, Xie YT, Hong XK, Chen YF, Liao LF, Lun ZR*. (2016) Pathogen Identification in an Imported Case of Cutaneous Leishmaniasis. Chin. J. Parasitol. Parasit. Dis. 34(3):295-296.] Jun 国家核心期刊

  40. Wen YZ, Lun ZR, Zhu XQ, Hide G, Lai DH*. (2016) Further evidence from SSCP and ITS DNA sequencing support Trypanosoma evansi and Trypanosoma equiperdum as subspecies or even strains of Trypanosoma brucei. Infect. Genet. Evol. 41:56–62. (影响因子: 3.0) July

  41. Lai DH*, Hong XK, Su BX, Liang C, Hide G, Zhang X, Yu X, Lun ZR. (2016) Current status of Clonorchis sinensis and clonorchiasis in China. Trans. R. Soc. Trop. Med. Hyg. 110:21–27. (影响因子: 1.8) Jan

  42. Lin RH, Lai DH*, Zheng LL, Wu J, Lukeš J, Hide G, Lun ZR* (2015). Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen. Parasit  Vectors. 8:665. (影响因子: 3.2) Dec

  43. Lun ZR*, Lai DH, Wen YZ, Zheng LL, Shen JL, Yang TB, Zhou WL, Qu LH, Hide G*, Ayala FJ* (2015) Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii. Proc. Natl. Acad. Sci. USA. July 112(29):8835–8842. (影响因子: 9.6)

  44. Flegontov P, Michalek J, Janouskovec J, Lai DH, Jirku M, Hajduskova E, Tomcala A, Otto TD, Keeling PJ, Pain A, Obornik M, Lukes J (2015) Divergent Mitochondrial Respiratory Chains in Phototrophic Relatives of Apicomplexan Parasites. Mol. Biol. Evol. May. 32(5): 1115–1131. DOI: 10.1093/molbev/msv021 (影响因子: 10.4)

  45. Carnes J, Anupama A, Balmer O, Jackson A, Lewis M, Brown R, Cestari1 I, Desquesnes M, Gendrin C, Hertz-Fowler C, Imamura H, Ivens A, Koreny L, Lai DH, MacLeod A, McDermott SM, Merritt C, Monnerat S, Moon W, Myler P, Phan I, Ramasamy G, Sivam D, Lun ZR*, Lukeš J*, Stuart K*, Schnaufer A* (2015) Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty. PLOS Negl. Trop. Dis. 9(1):e3404. (影响因子:4.4)

  46. Gao JM, Yi SQ, Wu MS, Geng GQ, Shen JL, Lu FL, Hide G, Lai DH(共同通讯作者), Lun ZR* (2015) Investigation of infectivity of neonates and adults from different rat strains to Toxoplasma gondii Prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection. Exp. Parasitol. 149(1): 47–53. (影响因子: 1.6)

  47. Xie YT, Lai DH, Liu GY, Zhou JL, Lun ZR* (2015) Severe fever with thrombocytopenia syndrome in China. Lancet Infect. Dis.  February 15(2): 145. (影响因子: 4)

  48. Lun ZR, Wen YZ, Uzureau P, Lecordier L, Lai DH,  Lan YG, Desquesnes M, Geng GQ, Yang TB, Zhou WL, Jannin JG, Simarro PP, Truc P, Vincendeau P, Pays E. (2015) Resistance to normal human serum reveals Trypanosoma lewisi as an underestimated human pathogen. Mol. Biochem. Parasitol. 199(1):58-61. (影响因子: 2.9)

  49. Lai DH, Poropat E, Pravia C, Landoni M, Couto AS, Pérez Rojo FG, Fuchs AG, Dubin M, Elingold I, Rodríguez JB, Ferella M, Esteva MI, Bontempi EJ*, Lukeš J* (2014) Solanesyl diphosphate synthase, an enzyme of the ubiquinone synthetic pathway, is required throughout the life cycle of Trypanosoma brucei. Euk. Cell. Feb 13(2): 320–328. (影响因子: 3.6)

  50. Desquesnes M, Holzmuller P, Lai DH, Dargantes A, Lun ZR, Jittapalapong S (2013)  Trypanosoma evansi and surra: A review and perspectives on origin, history & distribution, taxonomy, morphology, hosts and pathogenic effects. BioMed. Res. Int. 194176 Aug 19 (影响因子: 2.9)

  51. Desquesnes M, Holzmuller P, Lai DH, Dargantes A, Lun ZR, Jittapalapong S (2013)  Trypanosoma evansi and surra: A review and perspectives on transmission, epidemiology and control, impact, and zoonotic aspects. BioMed Res Int.321237 Sep 18 (影响因子: 2.9)

  52. Janouskovec J, Sobotka R(equal contribution),  Lai DH (共同第一作者), Flegontov P, Koník P, Komenda J, Ali S, Prásil O, Pain A, Oborník M, Lukes J, Keeling PJ (2013) Split photosystem protein, linear-mapping topology and growth of structural complexity in the plastid genome of Chromera velia. Mol Biol Evol. Nov;30(11):2447–62. doi: 10.1093/molbev/mst144. (影响因子: 10.4)

  53. Chen Y, Wen T, Lai DH, Wen YZ, Wu ZD, Yang TB, Yu XB, Hide G, Lun ZR* (2013) Development and evaluation of loop-mediated isothermal amplification (LAMP) for rapid detection of Clonorchis sinensis from its first intermediate hosts, freshwater snails. Parasitology. 2013 Sep;140(11):1377–83. doi: 10.1017/S0031182013000498. (影响因子: 2.4)

  54. Lai DH*, Bontempi EJ*, Lukeš J (2012) Trypanosoma brucei solanesyl-diphosphate synthase localizes to the mitochondrion. Mol. Biochem. Parasitol. 183(2):189–192. (影响因子: 2.9)

  55. Wang MH, Wen YZ, Wei Y, Lai DH, Bengaly Z, Desquesnes M, Lun ZR (2012) Mitogen-activated protein kinase 5, a novel molecular marker for the identification and detection of Trypanozoon species Acta Trop. 122(2):183–188. (影响因子: 2.3)

  56. 余新炳沈继龙 主编 赖德华 等编者 (2011) 现代病原生物学研究技术 人民卫生出版社 专著

  57. Wang QP, Lai DH, Li Z, Li FJ, Lun ZR (2011). Semicarbazide-sensitive amine oxidase kills African trypanosomes in vitro. Acta Trop. 2011 Feb 117(2): 161–164.  (影响因子:2.3 )

  58. Oborník M, Vancová M, Lai DH, Janouškovec J, Keeling PJ, Lukeš J (2011). Morphology and ultrastructure of multiple life cycle stages of the photosynthetic relative of apicomplexa, Chromera velia. Protist 2011 Jan 162(1): 115–130. (影响因子: 3.3)

  59. Lun ZR, Lai DH (共同第一作者), Li FJ,  Lukeš J, Ayala FJ. (2010) Trypanosoma brucei: two steps to spread out from Africa.Trends Parasitol. 2010 Sep 26(9): 424–427. (影响因子: 4.9)

  60. Lai DH, Wang QP, Li Z, Lukins AG, Reid SA, Lun ZR. (2010) Investigations into human serum sensitivity expressed by stocks of Trypanosoma brucei evansi. Int. J. Parasitol. 40(6): 705–710. (影响因子: 3.8)

  61. Hashimi H, Benkovičová V, Čermáková P, Lai DH, Horváth A, Lukeš J. (2010) The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei.  Int. J. Parasitol. 40(1): 45–54. (影响因子: 3.8)

  62. Lun ZR, Reid SA, Lai DH, Li FJ. (2009) Atypical human trypanosomiasis: a neglected disease or just an unlucky accident? Trends Parasitol. Mar 25(3): 107–108. (影响因子: 4.9)

  63. Lai DH(通讯作者), Wang QP, Li Z, Lukeš J, Lun ZR. (2009) Evolution of the serum resistance-associated SRA gene in African trypanosomes. Chin. Sci. Bull. 54(7):1275–1278. (影响因子: 1.0)

  64. Lai DH, Hashimi H, Lun ZR, Ayala FJ, Lukeš J. (2008) Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei. Proc. Natl. Acad. Sci. USA105(6): 1999–2004. (影响因子: 9.6)

  65. Lai DH, Wang QP, Chen W, Cai LS, Wu ZD, Zhu XQ, Lun ZR. (2008) Molecular genetic profiles among individual Clonorchis sinensis adults collected from cats in two geographic regions of China revealed by RAPD and MGE-PCR methods. Acta Trop. 107(2): 213–216. (影响因子: 2.2)

  66. Wang QP, Lai DH, Zhu XQ, Chen XG, Lun ZR. (2008) Human angiostrongyliasis. Lancet Infect. Dis. Aug 8(10): 621–630. (影响因子: 16.1)

  67. Li FJ, Gasser RB, Lai DH, Claes F, Zhu XQ and Lun ZR. (2007) PCR approach for the detection of Trypanosoma bruceiand T. equiperdum and their differentiation from T. evansi based on maxicircle kinetoplast DNA. Mol. Cell. Probes Feb 21(1): 1–7. (影响因子: 1.8)

  68. Li FJ, Lai DH, Lukeš J, Chen XG and Lun ZR. (2006) Doubts about Trypanosoma equiperdum strains classed as Trypanosoma brucei or Trypanosoma evansi. Trends Parasitol. 22(2): 55–56. (影响因子: 4.9)

  69. 戴晓俐, 赖德华, 伦照荣. (2006) 四种抗寄生原虫药物对伊氏锥虫、马媾疫锥虫和布氏锥虫感染的治疗作用. 热带医学杂志 6卷12期1240-1244,1248国家核心期刊

  70. Zhu S, Lai DH, Li SQ and Lun ZR. (2006) Stimulative effects of insulin on Toxoplasma gondii replication in 3T3-L1 cells. Cell Bio. Int. Feb 30(2): 149–153. (影响因子: 1.7) SCI E

  71. Lun ZR, Gasser RB, Lai DH, Li AX, Zhu XQ, Yu XB and Fang YY. (2005) Clonorchiasis: a key foodborne zoonosis in China. Lancet Infect. Dis. 5(1): 31–41. (影响因子: 10.8)