赌博app

性别:女
职称: 副教授
学历: 博士
电子邮件:[email protected]
导师类型: 博士生导师
学科方向
071010-生物化学与分子生物学
0860-生物与医药

研究方向

1.表观遗传修饰和基因表达调控方向研究；
2.胚胎干细胞维持自我更新和分化的表观遗传学研究。

个人经历

•    2022-至今，赌博app-网络赌博软件 ，副教授
•    2013-2022，赌博app-网络赌博软件 ，讲师
•    2012-2013，中国科学院广州生物医药与健康研究院，华南干细胞与再生医学研究所，助理研究员
•    2007-2012，华东师范大学生命医学研究所   博士 
•    2003-2007，吉林师范大学赌博app    学士 

讲授课程

生物化学I，遗传学实验，干细胞和细胞分化，衰老与抗衰老

学术成就

长期从事细胞命运调控的表观遗传机制研究，主要的研究方向（1）胚胎干细胞干性维持以及向生殖祖细胞定向分化的表观机制研究；（2）肿瘤细胞的端粒染色体的表观遗传维持机制。应用生物化学技术剖析组蛋白去甲基化酶PHF8的作用机理以及小鼠干细胞定向分化成神经细胞中的重要生物功能。该研究结果为XLMR疾病提供了表观遗传学的发病机理（Cell Research，2010，共同第一作者排二）；首次探究比较分析了同一去甲基化酶家族蛋白PHF2和PHF8在rDNA转录上的不同作用（Journal of Biological Chemistry，2014，共同第一作者排一）；筛选和鉴定了HP1BP3蛋白在染色质结构调控中的作用机制（Nucleic Acids Research，2020，共同第一作者排一）；以及揭示了类泛素化（SUMO）修饰抑制整体基因转录的新机制（Cell Research，2018，共同第一作者排二）。通过多能性因子（Oct4和Sox2）的蛋白组筛选中发现了维持干细胞多能性的新因子Ddx56蛋白（Stem Cell Research & Therapy，2020，独立通讯）；还发现间充质干细胞在皮肤损伤修复中新的应用策略（Stem Cell Research & Therapy，2020（a-b）（2021），共同通讯）。此外，总结了重复序列如逆转录转座子在多能性维持中的重要作用（Cell Regeneration，2020，共同通讯）；以第二或三发明人获得国家专利2项:（1）Bend5蛋白在提高胚胎干细胞诱导分化成原始生殖祖样细胞方面的应用（第三发明人）。（2）端粒结合蛋白HP1BP3在制备肿瘤细胞调控剂中的应用（第二发明人）。目前为止，本人在Cell Research、Nucleic Acids Research、Journal of Biological Chemistry等刊物上发表论文19篇，其中第一作者或通讯作者（含共同）11篇。获得国家自然科学基金青年项目、面上项目和广东省自然科学基金项目资助。

承担课题

2022-2025 国家自然科学基金面上项目
2019-2022 广东省自然科学基金面上项目
2017-2020 广东省自然科学基金自由申请项目（结题）
2017-2020 国家重点研发计划重点专项子课题骨干（结题）
2015-2016 中山大学青年教师培育项目（结题）
2014-2016 国家自然科学基金青年项目（结题）

论文专著

Guang Shi#,*, Qianwen Pang#, Zhancheng Lin, Xinyi Zhang, Kaimeng Huang. Repetitive Sequence Stability in Embryonic Stem Cells. International Journal of Molecular Sciences. 2024 Aug 13;25(16):8819.

Chuanle Wang#, Yan Huang#,*, Yue Yang, Ruofei Li, Yingying Li, Hongxin Qiu, Jiali Wu, Guang Shi, Wenbin Ma, Zhou Songyang*. ILF3 safeguards telomeres from aberrant homologous recombination as a telomeric R-loop reader. Protein Cell. 2024 Jul 1;15(7):493-511.

Jingran Zhang#, Guang Shi #, *, Junjie Pang, Xing Zhu, Qingcai Feng, Jie Na, Wenbin Ma, Dan Liu, Zhou Songyang*. Crotonylation of GAPDH regulates human embryonic stem cell endodermal lineage differentiation and metabolic switch. Stem Cell Research & Therapy. 2023 Apr 3;14(1):63.

Guang Shi, Yaofu Bai, Xiya Zhang, Junfeng Su, Junjie Pang, Quanyuan He, Pengguihang Zeng, Junjun Ding, Yuanyan Xiong, Jingran Zhang, Jingwen Wang, Dan Liu, Wenbin Ma, Junjiu Huang, Zhou Songyang*. Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation. Protein & Cell. 2022 Oct;13(10):721-741.

Jingran Zhang#, Junjie Pang#, Yaofu Bai, Zhancheng Lin, Junjiu Huang, Zhou Songyang, Guang Shi*. Global molecular features in transcription and chromatin accessibility in human extended pluripotent stem cells. Biochemical and Biophysical Research Communications, 2021 Aug 20; 574: 63-69.

Junyu Wu#, Chunyan Wu#, Fan Xing#, Liu Cao#, Weijie Zeng, Liping Guo, Ping Li, Yongheng Zhong, Hualian Jiang, Manhui Luo, Guang Shi, Lang Bu, Yanxi Ji, Panpan Hou, Hong Peng, Junjiu Huang, Chunmei Li, Deyin Guo*. Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells. Cell Research, 2021 Jun 22, 1–13.

Yiren Jiao, Xiaolin Chen, Yongxia Niu, Sunxing Huang, Jingwen Wang, Mingxun Luo, Guang Shi*, Junjiu Huang*. Wharton's jelly mesenchymal stem cells embedded in PF-127 hydrogel plus sodium ascorbyl phosphate combination promotes diabetic wound healing in type 2 diabetic rat. Stem Cell Research & Therapy. 2021 Oct 30;12(1):559.

Guang Shi#, Yang Hu#, Xing Zhu, Yuanling Jiang, Junjie Pang, Chuanle Wang, Wenjun Huang, Yong Zhao, Wenbin Ma, Dan Liu, Junjiu Huang*, Zhou Songyang*. A critical role of telomere chromatin compaction in ALT tumor cell growth. Nucleic Acids Research, 2020 Jun 19;48(11):6019-6031.

Jingwen Wang#, Jiahui Liu#, Miaoman Ye, Feng Liu, Su Wu, Junjiu Huang, Guang Shi*. Ddx56 maintains proliferation of mouse embryonic stem cells via ribosome assembly and interaction with the Oct4/Sox2 complex. Stem Cell Research & Therapy, 2020. 11:314

Qingzha Deng, Sunxing Huang, Jinkun Wen, Yiren Jiao, Xiaohu Su, Guang Shi*, Junjiu Huang*. PF-127 hydrogel plus sodium ascorbyl phosphate improves Wharton’s jelly mesenchymal stem cell-mediated skin wound healing in mice. Stem Cell Research & Therapy, 2020,11:143.

Jingwen Wang, Junjiu Huang*, Guang Shi*. Retrotransposons in pluripotent stem cells. Cell Regeneration. 2020. 9:4.

Zhuoheng Lin#, Puping Liang#, Zhaokai Yao, Yuxi Chen, Xiya Zhang, Rui Huang, Zhen Zhang, Minyan Li, Wenbin Ma, Haiyan Zheng, Shanbo Cao, Guang Shi, Xiaoyang Zhao, Zhou Songyang*, Junjiu Huang*. A novel undifferentiated spermatogonia-specific surface protein 1 (USSP1) in neonatal mice. Science Bulletin, 2019, 64:524–533.

Jianping Yu#, Weisi Lu#, Tianyu Ge, Rui Huang, Bohong Chen, Miaoman Ye, Yaofu Bai, Guang Shi, Zhou Songyang, Wenbin Ma*, Junjiu Huang*. Interaction Between Sympk and Oct4 Promotes Mouse Embryonic Stem Cell Proliferation. Stem Cells, 2019; 00:1–11.

Tingting Deng#, Yan Huang#,*, Kai Weng, Song Lin, Yujing Li, Guang Shi, Yali Chen, Junjiu Huang, Dan Liu, Wenbin Ma*, Zhou Songyang*.TOE1 acts as a 3’ exonuclease for telomerase RNA and regulates telomere maintenance. Nucleic Acids Research, 2019. 47:391-405.

Mingze Yao, Xueke Zhou, Jiajian Zhou, Shixin Gong, Gongcheng Hu, Jiao Li, Kaimeng Huang, Ping Lai, Guang Shi, Andrew P. Hutchins, Hao Sun, Huating Wang, Hongjie Yao*. PCGF5 is required for neural differentiation of embryonic stem cells. Nature Communications, 2018, 9:1463.

Fang Yu#, Guang Shi#, Shimeng Cheng, Jiwei Chen, Shwu-Yuan Wu, Zhiqiang Wang, Nansong Xia, Yunhao Zhai, Zhenxing Wang, Yu Peng, Dong Wang, James X. Du, Lujian Liao, Sheng-Zhong Duan, Tieliu Shi, Jinke Cheng, Cheng-Ming Chiang, Jiwen Li*, Jiemin Wong*. SUMO suppresses and MYC amplifies transcription globally by regulating CDK9 sumoylation. Cell Research, 2018, 28, 670-685.

Yang Hu#, Guang Shi#,*, Laichen Zhang, Feng Li, Yuanling Jiang, Shuai Jiang, Wenbin Ma, Yong Zhao, Zhou Songyang & Junjiu Huang*. Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX, Scientific Reports, 2016, 6:32280.

Kaimeng Huang#, Xiaobai Zhang#, Jiejun Shi#, Mingze Yao, Jiannan Lin, Jiao Li, He Liu, Huanhuan Li, Guang Shi, Zhibin Wang, Biliang Zhang, Jiekai Chen, Guangjin Pan, Cizhong, Jiang, Duanqing Pei*, Hongjie Yao*. Dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells. Scientific Reports. 2015, 5:17691.

Guang Shi#, Meng Wu#, Lan Fang, Fang Yu, Shimeng Cheng, Jiwen Li, James X. Du and Jiemin Wong*, PHD finger protein 2 (PHF2) represses ribosomal RNA gene transcription by antagonizing PHF finger protein 8 (PHF8) and recruiting methyltransferase SUV39H1, Journal of Biological Chemistry, 2014, 289, 29691-29700.

Sijie Zhang#, Zhenhua Luo, Guang Shi, Dan Liu, Zhou Songyang*, Junjiu Huang*. TPP1 as a versatile player at the ends of chromosomes. Frontiers in Biology, 2014.

Jihui Qiu#, Guang Shi#, Yuanhui Jia, Jing Li, Meng Wu, Jiwen Li, Shuo Dong* & Jiemin Wong*, The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation, Cell Research, 2010, 20, 908–918.  

Junjiang Fu#, Jun Jiang, Jiwen Li, Shanshan Wang, Guang Shi, Qin Feng, Eileen White, Jun Qin, Jiemin Wong*. Deleted in breast cancer 1, a novel androgen receptor (AR) coactivator that promotes AR DNA-binding activity. Journal of Biological Chemistry, 2009. 284(11): 6832-6840. 
 

 #共同第一作者， *共同通讯作者