性别:男
职称: 副教授
学历: 博士
电子邮件: [email protected]
导师类型: 博士生导师
学科方向:071004-水生生物学
0860-生物与医药
研究方向
水生经济动物病毒性病害之病原生物学、疫苗学与免疫生物学
学术成就
早期主要从事水生经济动物细菌性病害的研究，包括大宗淡水鱼常见细菌病和海水养殖鱼类弧菌病，在国内首先分离、鉴定并保种极高毒力鳗鲡创伤弧菌（生物1型）。
2005年—至今主要从事水生经济动物病毒性病害的病原生物、免疫和疫苗方面的研究工作。主持国家自然科学基金青年、面上，973子课题、博士后基金面上（一等）、博士后特别基金，教育部中央高校基金、中山大学应用性科技成果转化基金及广东渔业科技专项等多个项目，参与多项国家级、省级重点研发项目。在鱼虹彩病毒、疱疹病毒等水生病毒研究领域做出原创性学术贡献。以第一作者或通讯作者在JVI，Virology，Virus Res，Vet Microbiol，Aquaculture，Fish & shellfish Immunol及DCI等病毒学/兽医科学/水产学等领域的国际专业期刊发表研究论文30余篇。作为技术核心研制的《鳜传染性脾肾坏死病灭活疫苗（NH0618株）》获国家农业农村一类新兽药注册证书【（中华人民共和国农业农村部公告 第253号,（2019）新兽药证字75号）】，当前在全国范围进行推广应用。
论文专著
（一）、研究论文
Selected Peer-reviewed Published Articles (* or**, corresponding author)：
37. Fu, W., Li, Y., Fu, Y., Zhang, W., Luo, P., Sun, Q., Yu F, Weng S, Li W He J & Dong, C*. (2023). The Inactivated ISKNV-I Vaccine Confers Highly Effective Cross-Protection against Epidemic RSIV-I and RSIV-II from Cultured Spotted Sea Bass Lateolabrax maculatus. Microbiology Spectrum 11(3), e04495-22.
36. Fu, Y., Li, Y., Chen, J., Yu, F., Liu, X., Fu, W., Pan, H., Li, W., Weng S., He, J., Dong, C*, 2023. A mandarinfish Siniperca chuatsi infection and vaccination model for SDDV and efficacy evaluation of the formalin-killed cell vaccine in yellowfin seabream Acanthopagrus latusAquaculture 570.
35. Zhang, W., Deng, H., Fu, Y., Fu, W., Weng, S., He, J., & Dong, C* (2023). Production and characterization of monoclonal antibodies against mandarinfish ranavirus and first identification of pyloric caecum as the major target tissue. J Fish Dis, 46(3), 189-199. doi:10.1111/jfd.13733.
34. Fu, Y., Li, Y., Zhang W, Fu, W., Li W, Zhu Z, Weng, S., He, J., Dong, C*, 2023. Effectively protecting Asian seabass Lates calcarifer from ISKNV-I, ISKNV-II, RSIV-II and SDDV by an inactivated ISKNV-I and SDDV bivalent vaccine. Aquaculture 566, 739218.
33. Sun Y, Weng S, Xu B, Dong C*., He J*. 2023. Iron loss and hypoxia are involved in lethal Pseudomonas plecoglossicida infections in the orange-spotted grouper Epinephelus coioides. Aquaculture 563, 739015
32. Fu, Y., Li, Y., Liu, X., Fu, W., Weng, S., Yu, F., He, J., Dong, C*, 2022. Development of two cell lines from yellowfin sea bream (Acanthopagrus latus) fin and brain suitable for propagating SDDV but not for ISKNV, MRV and GIV-R. Aquaculture, 560, 738478
31. Zhang, H., Qi, H., Weng, S., He, J*., & Dong, C*. 2022. Deleting ORF71L of infectious spleen and kidney necrosis virus (ISKNV) resulted in virulence attenuation in Mandarin fish. Fish & Shellfish Immunology. Volume 123, April 2022, Pages 335-347
30. Liu, F., Weng, S., He, J., Dong, C*, 2022. Cyclophilin A is incorporated into cyprinid herpesvirus 3 (CyHV-3) virion via interaction with envelope VP32 and facilitates CyHV-3 replication in in vitro. Aquaculture, 737943.
29. Fu Y, Li Y, Fu W, Su H, Zhang L, Huang C, Weng S, Yu F, He J*, Dong, C*. 2021. Scale Drop Disease Virus Associated Yellowfin Seabream (Acanthopagrus latus) Ascites Diseases, Zhuhai, Guangdong, Southern China: The First Description. Viruses, 13(8):1617. doi: 10.3390/v13081617
28. Zhu Z, Duan C, Li Y, Huang C, Weng S, He J and Dong, C*. 2021. Pathogenicity and histopathology of infectious spleen and kidney necrosis virus genotype II (ISKNV-II) recovering from mass mortality of farmed Asian seabass, Lates calcarifer, in Southern China.Aquaculture, 534 (2021) 736326.
27. Sun Y, Zhu Z, Weng S, He J and Dong, C*. 2020. Characterization of a highly lethal barramundi (Lates calcarifer) model of Pseudomonas plecoglossicida infection. Microbial Pathogenesis, 149 (2020), 104516.
26 Zhu Zhiming, Duan Chao, Dong, C*, Weng Shaoping and He Jianguo*. 2020. Epidemiological situation and phylogenetic relationship ofVibrio harveyi in marine-cultured fishes in China and Southeast Asia. Aquaculture, 529 (2020) 735652.
25. Zhang W, Duan C, Weng S, He J and Dong, C*. 2020. Widespread outbreaks of the emerging mandarinfish ranavirus (MRV) both in natural and ISKNV-FKC vaccinated mandarinfish Siniperca chuatsi in Guangdong, South China, 2017. Aquaculture, 520 (2020) 734989.
24. Zhu Z, Dong C*., Weng S., He J*. 2019. Identification of outer membrane protein TolC as the major adhesin and potential vaccine candidate for Vibrio harveyi in hybrid grouper, Epinephelus fuscoguttatus (♀) × E. lanceolatus (♂). Fish Shellfish Immunol. 86:143-151.
23. Gao Y, Suárez Nicolás M., Wilkie Gavin S., Dong C, 2018. Bergmann Sven, Lee Pei Yu Alison, Davison Andrew J., Vanderplasschen Alain F. C.* and Boutier Maxime. 2018. Genomic and biologic comparisons of cyprinid herpesvirus 3 strains. Vet Res (2018) 49:40.
22. Zhu Z, Dong C*, Weng S and He J*. 2018. The high prevalence of pathogenic Vibrio harveyi with multiple antibiotic resistance in scale drop and muscle necrosis disease of the hybrid grouper, Epinephelus fuscoguttatus (♀) × E. lanceolatus (♂), in China. J Fish Dis. 41(4):589-601.
21. Dong C*, Wang Z, Weng S and He J 2017. Occurrence of a lethal ranavirus in hybrid mandarin (Siniperca scherzeri × Siniperca chuatsi) in Guangdong, South China. Vet microbiol,203,28-33.
20. Lee X, Weng S, Zhang H, Zeng J, He J* and Dong C* 2016. Identification and expression analysis of cellular and viral microRNAs in CyHV3-infected KCF-1 cells. Gene, 592(1):154-63.
19. Qi H, Yi Y, Weng S, Zou W, He J* and Dong C*., 2016. Differential autophagic effects triggered by five different vertebrate iridoviruses in a common, highly permissive mandarinfish fry (MFF-1) cell model. Fish Shellfish Immunol.49, 407-419.
18. Lee X, Yi Y, Weng S, Zeng J, Zhang H, He J* and Dong C*., 2016. Transcriptomic analysis of koi (Cyprinus carpio) spleen tissue upon cyprinid herpesvirus 3 (CyHV3) infection using next generation sequencing. Fish Shellfish Immunol. 49, 213-224.
17. Yi, Y., Qi, H., Yuan, J., Wang, R., Weng, S., He, J., Dong, C*., 2015. Functional characterization of viral tumor necrosis factor receptors encoded by cyprinid herpesvirus 3 (CyHV3) genome. Fish Shellfish Immunol. 45 (2), 757-770.
16. Li, W., Lee, X., Weng, S., He, J*., Dong, C*. 2015. Whole-genome sequence of a novel Chinese cyprinid herpesvirus 3 isolate reveals the existence of a distinct European genotype in East Asia. Vet microbiol, 175, 185-194.
15. Dong C*, Shuang F, Weng S and He J. 2014. Cloning of a new fibroblast cell line from an early primary culture from mandarin fish(Siniperca chuatsi) fry for efficient proliferation of megalocytiviruses. Cytotechnology, 66:883–890.
14. Yi Y, Zhang H, Lee X, Weng S, He J and Dong C*. 2014. Extracellular virion proteins of two Chinese CyHV-3/KHV isolates, and identification of two novel envelope proteins. Virus Res 191, 108-116.
13. Xiang Z, Weng S, Qi H, He J and Dong C*. 2014. Identification and characterization of a novel FstK-like protein from spotted knifejaw iridovirus (genus Megalocytivirus). Gene, 545, 233-240.
12. Li, W., Zhang, X., Weng, S., Zhao, G., He, J., Dong, C. *. 2014. Virion-associated viral proteins of a Chinese giant salamander (Andrias davidianus) iridovirus (genus Ranavirus) and functional study of the major capsid protein (MCP). Vet Microbiol, 172, 129-139.
11. Dong C*, Li X, Weng S, Xie S and He J*. 2013. Emergence of fatal European genotype CyHV-3/KHV in mainland China. Vet microbiol,162(1):239-44.
10. Shuang F, Luo Y, Xiong X, Weng S, Li Y, He J*, and Dong C**. 2013. Virion proteins of an RSIV type megalocytivirus from spotted knifejawOplegnathus punctatus (SKIV-ZJ07). Virology, 437(2): 89-99.
9. Dong C, Xiong X, Luo Y, Weng S, Wang Q and He J*.. 2013. Efficacy of a formalin-killed cell vaccine against infectious spleen and kidney necrosis virus (ISKNV) and immunoproteomic analysis of its major immunogenic proteins. Vet microbiol, 162(2-4): 419-428.
8. Dong, Y., Weng, S., He, J., Dong, C*. 2013. Field trial tests of FKC vaccines against RSIV genotype Megalocytivirus in cage-cultured mandarin fish (Siniperca chuatsi) in an inland reservoir. Fish Shellfish Immuno, l 35, 1598-1603.
7. Dong C, Weng S, Li W, Li X, Yi Y, Liang Q, He J*. 2011. Characterization of a new cell line from caudal fin of koi, Cyprinus carpio koi, and first isolation of cyprinid herpesvirus 3 in China. Virus Res, 161(2):140-9.
6. Dong C, Xiong X, Shuang F, Weng S, Zhang J, Zhang Y, Luo Y, He J*. 2011. Global landscape of structural proteins of infectious spleen and kidney necrosis virus. J Virol,;85(6):2869-77.
5. Xiang Z, Dong C (Co-first authors), Qi L, Chen W, Huang L, Li Z, Xia Q, Liu D, Huang M, Weng S, He J*. 2010. Characteristics of the interferon regulatory factor pairs zfIRF5/7 and their stimulation expression by ISKNV Infection in zebrafish (Danio rerio). Dev Comp Immunol, 34(12):1263-73.
4. Xiong X, Dong C, Weng S, Zhang J, Zhang Y, He J*. 2011. Antigenic identification of virion structural proteins from infectious spleen and kidney necrosis virus. Fish Shellfish Immunol, 31(6):919-24.
3. Xiong X, Dong C, Xu X, Weng S, Liu Z, He J*. 2011. Proteomic analysis of zebrafish (Danio rerio) infected with infectious spleen and kidney necrosis virus. Dev Comp Immunol, 35(4):431-40.
2. Dong C, Weng S, Luo Y, Huang M, Ai H, Yin Z, He J*. 2010. A new marine megalocytivirus from spotted knifejaw, Oplegnathus punctatus, and its pathogenicity to freshwater mandarinfish, Siniperca chuatsi. Virus Res, 147(1):98-106.
1. Dong C, Weng S, Shi X, Xu X, Shi N, He J*. 2008. Development of a mandarin fish Siniperca chuatsi fry cell line suitable for the study of infectious spleen and kidney necrosis virus (ISKNV). Virus Res, 135(2):273-81.
（二）、发明专利或生物制品
1，发明专利：何建国，董传甫，殷志新，翁少萍。传染性脾肾坏病毒疫苗及其制备方法和应用，专利号：ZL200910038692.8。授权时间，2012.2。
2，新兽药注册证书（一类）：《鳜传染性脾肾坏死病灭活疫苗（NH0618株）》，农业农村部一类新兽药证书【（中华人民共和国农业农村部公告 第253号，（2019）新兽药证字75号）】，2019年12月30日。
（三）、国际学术会议：
1，Dong C *, Shuang F, Weng S, He J. Virion proteins of an RSIV type megalocytivirus from spotted knifejaw Oplegnathus punctatus (SKIV-ZJ07). XIX Poxvirus, Asfarvirus and Iridovirus conference. Salamanca in Spain, 25-29 June 2012. Presentation as a POSTER.
2，Dong C * and He J, A mini-review on fish iridovirus and iridoviral diseases: emphasis on Megalocytivirus. Asian Aquaculture Conference, 3-6 December, 2018, AIT BANKOK, THAILAND.
