性别: 男
工作电话:021-84113793
职称:副教授
电子邮件: [email protected]
导师类型: 硕士生导师
学历:博士研究生毕业
学科方向: 071004-水生生物学
0860-生物与医药
研究方向
水生生物免疫调控
水生生物信号通路调控
miRNA功能研究
对虾生物钟
个人经历
2005.09-2009.06，安徽农业大学，植物保护学专业，农学学士;
2009.09-2012.06，华南农业大学，农药学专业，农学硕士;
2012.09-2015.06，中山大学，食品安全生物学，理学博士。
2015.09-2017.09，中山大学，博士后；
2017.09-2022.09，中山大学，专职科研（特聘研究员）；
2022.10至今，中山大学，副教授。
学术成就
主要从事对虾抗病免疫分子机制相关研究，聚焦对虾养殖产业中白斑综合症病毒（WSSV）发病快，难以进行及时有效的防控和对虾抗病毒性状与抗细菌性状相拮抗这两个产业难题，从小分子RNA角度出发，围绕microRNA调节对虾NF-κB和JAK-STAT信号通路的分子机制开展了一系列研究，（1）揭示了WSSV通过miR-1959介导的对虾抗细菌反馈环路促进自身复制，同抑制对虾抗病毒通路，逃逸宿主免疫的分子机制，解释了WSSV发病快，难以进行及时有效的防控的原因；（2）揭示了对虾JAK-STAT和NF-κB信号通路分别通过miR-1和miR-34介导的两条调控途径相互抑制的分子机制，解释了对虾抗病毒性状和抗细菌性状相拮抗的原因。在从事对虾抗病毒和抗细菌免疫研究的过程中，（3）鉴定了两种分别抑制对虾的抗病毒和抗细菌信号通路的孤核受体，在此基础上，开发了一种能有效增强对虾的抗病毒能力的饲料添加剂，并授权了一项国家发明专利，申请获得了包括面上项目和青年基金在内的国家级项目2项，省部级及其它项目5项，以第一作者或通迅作者身份在The Journal of Immunology、Frontiers in Immunology、Aquaculture和Fish and Shellfish Immunology等杂志上发表文章十余篇。
承担课题
1. 国家自然科学基金面上项目，对虾生物钟系统调控JAK/STAT通路昼夜节律的分子机制，31972823，2020.01-2023.12，58万元，主持，在研；
2. 广州市基础与应用基础研究，枯草芽孢杆菌表达dsRNA抑制孤核受体增强对虾抗病能力的分子机制，202201011352，2022.04-2024.03，5万元，主持，在研；
3. 国家自然科学基金青年基金项目，MicroRNA-34介导的NF-κB调节JAK/STAT通路的分子机制，31702371，2018.01-2020.12，25万元，主持，已结题；
4. 中山大学高校基本科研业务费项目，MicroRNA介导的凡纳滨对虾NF-κB信号通路活性动态平衡机制，18lgpy57，2019.01-2021.12，15万元，主持，已结题；
5. 中国博士后科学基金（一等资助），对虾一种NF-kB/microRNA/IkB反馈调节环路及其调控机制，2015M580746，2015.10-2017.10，8万元，主持 ，已结题。
论文专著
Mengting Luo#, Xiaopeng Xu#, Xinxin Liu, Linwei Yang, Wenjie Shen, Shaoping Weng, Jianguo He*, Hongliang Zuo*. The non-receptor protein tyrosine phosphatase PTPN6 mediates a positive regulatory approach from interferon regulatory factor to JAK/STAT pathway in Litopenaeus vannamei. Frontiers in Immunology, 2022, 13(6)：913955.
Hongliang Zuo, Xinxin Liu, Mengting Luo, Linwei Yang, Zhiming Zhu, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. miR-10c facilitates white spot syndrome virus infection by targeting toll3 in Litopenaeus vannamei. Frontiers in Immunology, 2021, 12: 1-15.
Kejia Weng#, Hongliang Zuo#, Zhiming Zhu, Zhixun Guo, Shaoping Weng, Jianguo He, Xiaopeng Xu*. Ftz-F1H promotes white spot syndrome virus infection in shrimp by suppressing the Dorsal pathway. Aquaculture, 2022, 548: 1-7.
Hongliang Zuo#, Kejia Weng#, Zhiming Zhu, Zhixun Guo, Shaoping Weng, Jianguo He, Xiaopeng Xu*. Suppression of a JAK-STAT pathway target gene Ftz-F1H enhances the resistance of shrimp to Vibrio parahaemolyticus. Aquaculture, 2021, 543: 1-10.
Hongliang Zuo, Kejia Weng, Mengting Luo, Linwei Yang, Shaoping Weng, Jianguo He*, Xiappeng Xu*. A microRNA-1-Mediated Inhibition of the NF-κB pathway by the JAK-STAT pathway in the invertebrate Litopenaeus vannamei. TheJournal of Immunology, 2020, 204(11): 1-13.
Hongliang Zuo#, Jia Yuan#, Linwei Yang, Zhiwei Liang, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. Characterization and immune function of the thioredoxin-interacting protein (TXNIP) from Litopenaeus vannamei. Fish and Shellfish Immunology, 2019, 84(1): 20-27.
Hongliang Zuo#, Linwei Yang#, Jiefu Zheng, Ziqi Su, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. A single C4 Zinc finger-containing protein from Litopenaeus vannamei involved in antibacterial responses. Fish and Shellfish Immunology, 2018, 81(10): 493-501.
Hongliang Zuo#, Jia Yuan#, Linwei Yang, Jiefu Zheng, Shaoping Weng, Jianguo He, Xiaopeng Xu*. Identification of the thioredoxin-related protein of 14 kDa (TRP14) from Litopenaeus vannamei and its role in immunity. Fish and Shellfish Immunology, 2018, 80(9): 514-520.
Song Shi#, Hongliang Zuo#, Lu Gao, Xin Yi, Guohua Zhong*. Silencing of Rieske Iron-Sulfur protein impacts upon the development and reproduction of Spodoptera exigua by regulating ATP synthesis. Frontiers in Physiology, 2018, 9: 1-12.
Hongliang Zuo, Jia Yuan, Shengwen Niu, Linwei Yang, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. A molting-inhibiting hormone-like protein from Pacific white shrimp Litopenaeus vannamei is involved in immune responses. Fish and Shellfish Immunology, 2018, 72(1): 544-551.
Jiefeng Gao#, Hongliang Zuo#, Linwei Yang, Jianhui He, Shengwen Niu, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. Long-term influence of cyanobacterial bloom on the immune system of Litopenaeus vannamei. Fish and Shellfish Immunology, 2017, 61(2): 79-85.
Hongliang Zuo#, Jiefeng Gao#, Jia Yuan, Hengwei Deng, Linwei Yang, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. Fatty acid synthase plays a positive role in shrimp immune responses against Vibrio parahaemolyticus infection. Fish and Shellfish Immunology, 2017, 60(1): 282-288.
Xiaopeng Xu, Jia Yuan, Linwei Yang, Shaoping Weng, Jianguo He*, Hongliang Zuo*. The Dorsal/miR-1959/Cactus feedback loop facilitates the infection of WSSV in Litopenaeus vannamei. Fish and Shellfish Immunology, 2016, 56(9): 397-401.
Hongliang Zuo, Jia Yuan, Yonggui Chen, Sedong Li, Ziqi Su, Erman Wei, Chaozheng Li, Shaoping Weng, Xiaopeng Xu*, Jianguo He*. A microRNA-mediated positive feedback regulatory loop of the NF-κB pathway in Litopenaeus vannamei. The Journal of Immunology, 2016, 196(9): 3842-3853.
Hongliang Zuo, Haoyang Li, Erman Wei, Ziqi Su, Jieyao Zheng, Chaozheng Li, Yonggui Chen, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. Identification and functional analysis of a Hemolin like protein from Litopenaeus vannamei. Fish and Shellfish Immunology, 2015, 43(1): 51-59.
Hongliang Zuo, Lu Guo, Zhen Hu, Haiyuan Liu, Guohua Zhong*. Cloning, expression analysis, and molecular modeling of the gamma-aminobutyric acid receptor alhpa2 subunit gene from the common cutworm, Spodoptera litura. Journal of Insect Science, 2013, 13: 1-13.
