个人经历:
1995年获美国波士顿塔夫兹大学生命医学学院分子和细胞生理学博士学位;
1995年-1998年于哈佛大学医学院细胞生物学系、麻省理工学院(MIT)生物系从事博士后工作;
1998年起 在美国贝勒医学院任助理教授,历任副教授、正教授和讲席教授;
2009年受聘为中山大学教授;
2009-2015年,任赌博app-网络赌博软件 院长;
2011至今中山大学抗衰老中心主任、广州市抗衰老重点实验室主任
国家重大科学研究计划项目和重点专项首席科学家。国家自然科学基金“器官衰老”重大研究计划专家组副组长。中国生物化学与分子生物学会常务理事,中国老年协会衰老和抗衰老科学委员会常务委员;曾任科技部“干细胞研究”国家重大科学研究计划专家组成员、国家自然科学基金委生命科学部专家咨询委员会委员。
讲授课程:
《生命科学引论》
学术成就:
以通讯作者或第一作者在国际顶级学术杂志Nature, Cell, Science, Nature子刊, PNAS, Cell子刊封面文章发表,主要研究成果包括:1)首次发现了TRF1等六个主要的端粒蛋白能形成telosome/shelterin端粒体;创造性地提出“端粒 Interactome”,系统地分析了人体细胞调节端粒的蛋白质网络,发现了一个新的端粒结合蛋白PTOP/TPP1参与端粒的调节;并发现TIN2 和 POT1 形成异聚体调控端粒酶,TPP1通过磷酸化调控细胞周期倚赖的端粒酶招募,首次发现了端粒体成分TIN2参与了细胞代谢调控,创新地联系了衰老的两大生物学问题——端粒和线粒体代谢,赌博app相关的文章。相关论文入选Faculty of 1000。2)开发了BiFC(双分子荧光互补系统)和蛋白片段互补(Protein-Fragment Complementation Assays,PCA)技术平台,并已成功应用在许多不同生物学领域和各信号通路的研究。3)发明了两种独特的导向性多肽库(Oriented Peptide library and OPAL)技术,用于高通量系统性地研究各种蛋白质信号基团之间的特异性作用。4)开发了若干从哺乳动物细胞中筛选功能性基因的新技术,例如基于逆转录病毒的ERM新技术(增强性逆转录病毒突变方法),该研究方法极大地推动了信息传导以及蛋白质相互作用研究。5)研发了基因编辑的新方法,利用于研究胚胎发育和疾病机理的研究。6)胚胎干细胞的蛋白组学和功能性的研究等相关领域处于国内外相关领域的前沿。
归国工作以来松阳洲教授衔接基础研究和应用转化,获得科技部国家重大科学研究计划的资助并任项目首席科学家,并获得国家自然科学基金重大研究计划、重点项目等多项国家级和省部级项目的资助。迄今已在Nature, Science, Cell, PNAS, Nature Cell Biology, NSMB, Molecular Cell等国际知名杂志上发表论文130多篇,总引用次数超过13000次,2017年H-index为61。曾荣获Scientist报年度最佳论文奖和Cell杂志30年最佳30篇文章奖,Irvington Institute Postdoctoral Fellowship, Ellison New Scholar,American Cancer Society Scholar与Leukemia and Lymphoma Society Scholar等荣誉。
论文专著:
The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation. He Q, Kim H, Huang R, Lu W, Tang M, Shi F, Yang D, Zhang X, Huang J, Liu D, Songyang Z. Cell Stem Cell. 2015 Sep 3;17(3):273-86.
Mir-23a Induces Telomere Dysfunction and Cellular Senescence by Inhibiting TRF2 Expression. Luo ZH, Feng XY, Wang HL, Xu WW, Zhao Y, Ma WB, Jiang SS, Liu D, Huang JJ*, Songyang Z*. Aging Cell 2014. (in press)
TPP1 as a versatile player at the ends of chromosomes. Zhang, S., Luo, Z., Shi, G., Liu, D., Songyang, Z.,Huang, J.(2014). Frontiers in Biology 9,225-233.
Structural Maintenance of Chromosomes Flexible Hinge Domain Containing 1 (SMCHD1) Promotes Non-homologous End Joining and Inhibits Homologous Recombination Repair upon DNA Damage. Tang, M., Li, Y., Zhang, X., Deng, T., Zhou, Z., Ma, W., and Songyang, Z. (2014a). J Biol Chem 289, 34024-34032.
Disease mutant analysis identifies a novel function of DAXX in telomerase regulation and telomere maintenance. Journal of cell science. Tang, M., Li, Y., Zhang, Y., Chen, Y., Huang, W., Wang, D., Zaug, A.J., Liu, D., Zhao, Y., Cech, T.R., et al. (2014b).
Human Urine-Derived Stem Cells Alone or Genetically-Modified with FGF2 Improve Type 2 Diabetic Erectile Dysfunction in a Rat Model. Ouyang B, Sun X, Han D, Chen S, Yao B, Gao Y, Bian J, Huang Y, Zhang Y, Wan Z, Yang B, Xiao H, Songyang Z, Liu G, Zhang Y, Deng C. PLoS One. 2014 Mar 24;9(3):e92825. doi: 10.1371/journal.pone.0092825. eCollection 2014.
Fam118B, a novel component in Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. Li Y, Fong KW, Tang M, Han X, Gong Z, Ma W, Hebert M, Songyang Z, Chen J. J Cell Sci. 2014 Feb 25. [Epub ahead of print]
Telomere regulation in pluripotent stem cells. Huang Y, Liang P, Liu D, Huang J, Songyang Z. Protein Cell. 2014 Mar;5(3):194-202. doi: 10.1007/s13238-014-0028-1. Epub 2014 Feb 22.
The Death-inducer Obliterator 1 (Dido1) Gene Regulates Embryonic Stem Cell Self-renewal. Liu Y, Kim H, Liang J, Lu W, Ouyang B, Liu D, Songyang Z. J Biol Chem. 2014 Feb 21;289(8):4778-86. doi: 10.1074/jbc.M113.486290. Epub 2013 Dec 17.
Whole-genome screening identifies proteins localized to distinct nuclear bodies. Fong KW1, Li Y, Wang W, Ma W, Li K, Qi RZ, Liu D, Songyang Z, Chen J. J Cell Biol. 2013 Oct 14;203(1):149-64. doi: 10.1083/jcb.201303145.
Large-scale screens of miRNA-mRNA interactions unveiled that the 3'UTR of a gene is targeted by multiple miRNAs. Zhou P, Xu W, Peng X, Luo Z, Xing Q, Chen X, Hou C, Liang W, Zhou J, Wu X, Songyang Z, Jiang S. PLoS One. 2013 Jul 9;8(7):e68204. doi: 10.1371/journal.pone.0068204. Print 2013.
Ten-eleven translocation 1 (tet1) is regulated by o-linked N-acetylglucosamine transferase (ogt) for target gene repression in mouse embryonic stem cells. Shi, F.T., Kim, H., Lu, W., He, Q., Liu, D., Goodell, M.A., Wan, M., and Songyang Z.*. 2013 Jul 19J Biol Chem 288, 20776-20784.
The telomere-associated homeobox-containing protein TAH1 participates in telomere maintenance in ALT Cells. Xuyang Feng, Zhenhua Luo, Shuai Jiang, Feng Li, Xin Han, Yang Hu, Dan Wang, Yong Zhao, Wenbin Ma, Dan Liu, Junjiu Huang, and Zhou Songyang. J Cell Sci jcs.128512; Advance Online Article June 26, 2013, doi:10.1242/jcs.128512
Akt regulates TPP1 homodimerization and telomere protection. Xin Han, Dan Liu, Yi Zhang, Yujing Li, Weisi Lu, Junjie Chen, Zhou Songyang. Aging Cell. Volume 12, Issue 6, pages 1091–1099, December 2013 .Article first published online: 11 AUG 2013 DOI: 10.1111/acel.12137.
Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment. Zhang Y, Chen LY, Han X, Xie W, Kim H, Yang D, Liu D, Songyang Z. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5457-62. doi: 10.1073/pnas.1217733110. Epub 2013 Mar 18.
MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma, Liu D, Songyang Z, Chen J.J Cell Sci. 2012 Dec 21. [Epub ahead of print]