付永贵，性别：男，电子邮件：[email protected]，职称：教授，导师类型：博士生导师，学历：博士研究生
学科方向：
071010-生物化学与分子生物学
0860-生物与医药
研究方向
医药生化与分子生物学：可选择性多聚腺苷酸化的机制和功能（APA）
APA是真核生物mRNA转录加工的重要过程之一，可产生具有不同长度3‘UTR的mRNA异构体，可以影响mRNA的稳定性、翻译效率及亚细胞定位，从而影响到胚胎及干细胞分化、免疫应答、肿瘤发生、应激反应的生命现象。
我们率先开发了基于高通量测序技术的SAPAS及IVT-SAPAS技术，在全转录组水平上研究APA的功能和调控机制。
讲授课程
本科生课程：
高通量生物学与数据分析
生物化学实验
研究生课程：
实验设计与数据分析
承担课题
（主持）国家自然科学基金面上项目：结直肠癌细胞PABPN1精氨酸甲基化通过相分离调控可选择性多聚腺苷酸化的分子机制研究，2025.1-2028.12, 50万元
（参与）国家重点研发计划：干细胞成瘤的时空演化规律研究，2023.1-2027.12，210万元；
（主持）国家自然科学基金面上项目：可选择性多聚腺苷酸化的分子功能，2020.1-2023.12, 59万元。
论文专著
- Zhijie Hu#, Mengxia Li#, Yufeng Chen#, Liutao Chen, Yuting Han, Chengyong Chen, Xin Lu, Nan You, Yawen Lou, Yingye Huang, Zhanfeng Huo, Chao Liu, Cheng Liang, Susu Liu, Ke Deng, Liangfu Chen, Shangwu Chen, Guohui Wan, Xiaojian Wu*, Yonggui Fu* and Anlong Xu*. Disruption of PABPN1 phase separation by SNRPD2 drives colorectal cancer cell proliferation and migration through promoting alternative polyadenylation of CTNNBIP1. Sci. China Life Sci., 2024, 67(6): 1212~1225. DOI：10.1007/s11427-023-2495-x.
- Susu Liu#, Runze Wu#, Liutao Chen#, Ke Deng, Xin Ou, Xin Lu, Mengxia Li, Chao Liu, Shangwu Chen, Yonggui Fu* and Anlong Xu*. CPSF6 regulates alternative polyadenylation and proliferation of cancer cell through phase separation. Cell Rep., 2023, 42(10): 113197. DOI: 10.1016/j.celrep.2023.113197.
- Liutao Chen#, Yonggui Fu#, Zhijie Hu, Ke Deng, Zili Song, Susu Liu, Mengxia Li, Xin Ou, Runze Wu, Mian Liu, Rui Li, Shuiying Gao, Lin Cheng, Shangwu Chen and Anlong Xu*. Nuclear m6A reader YTHDC1 suppresses proximal alternative polyadenylation sites by interfering with the 3' processing machinery. EMBO Rep., 2022, 23(11): e54686. DOI: 10.15252/embr.202254686.
- Zhijie Hu#, Mengxia Li#, Zhanfeng Huo#, Liutao Chen, Susu Liu, Ke Deng, Xin Lu, Shangwu Chen, Yonggui Fu* and Anlong Xu*. U1 snRNP proteins promote proximal alternative polyadenylation sites by directly interacting with 3' end processing core factors. J Mol Cell Biol., 2022, 14(8), mjac054.
- Yonggui Fu#, Liutao Chen#, Chengyong Chen, Yutong Ge, Mingjing Kang, Zili Song, Jingwen Li, Yuchao Feng, Zhanfeng Huo, Guopei He, Mengmeng Hou, Shangwu Chen, Anlong Xu*. Crosstalk between alternative polyadenylation and miRNAs in the regulation of protein translational efficiency, Genome Res., 2018, 28(11): 1656~1663
- Qiong Wang, Guopei He, Mengmeng Hou, Liutao Chen, Shangwu Chen, Anlong Xu*, Yonggui Fu*. Cell cycle regulation by alternative polyadenylation of CCND1. Sci Rep., 2018, 8: 6824.
- Feifei Qiu#, Yonggui Fu#, Chan Lu, Yuchao Feng, Qiong Wang, Zhanfeng Huo, Xin Jia, Chengyong Chen, Shangwu Chen, Along Xu*. Small Nuclear Ribonucleoprotein Polypeptide A-Mediated Alternative Polyadenylation of STAT5B during Th1 Cell Differentiation, J Immunol., 2017, 199(9): 3106~3115.
- Yuxin Li#, Yu Sun#, Yonggui Fu#, Mengzhen Li, Guangrui Huang, Chenxu Zhang, Jiahui Liang, Shengfeng Huang, Gaoyang Shen, Shaochun Yuan, Liangfu Chen, Shangwu Chen, Anlong Xu*. Dynamic landscape of tandem 3' UTRs during zebrafish development. Genome Res., 2012, 22(10): 1899~1906.
- Yonggui Fu#, Yu Sun#, Yuxin Li#, Jie Li, Xingqiang Rao, Chong Chen, Anlong Xu*. Differential genome-wide profiling of tandem 3' UTRs among human breast cancer and normal cells by high-throughput sequencing. Genome Res., 2011, 21(5): 741~747.
