性别: 女
个人主页: //shimeigroup.duboapp.net/; 微信公众号 Zhuang SM Group
职称: 教授
电子邮件: [email protected]
导师类型: 博士生导师
学历:博士研究生
学科方向
071009-细胞生物学
071010-生物化学与分了生物学
研究方向
肝癌发生发展的分子机制；肝癌精准诊疗标志物
个人经历
庄诗美教授1987年毕业于复旦大学上海医学院六年制临床医学专业，1992年获该校儿科学医学博士学位，随后被该校医学神经生物学国家重点实验室聘为讲师，1993年自费出国。
1993至1994年作为访问学者在荷兰Leiden大学从事细胞凋亡的研究工作。1995至2002年在瑞典Linkoping大学从事化学物致癌的机制研究，其间于1999年获细胞生物学理学博士学位，于2000年被聘为助理教授。
2002年底到中山大学工作。先后入选/获得教育部长江学者特聘教授、国家杰出青年科学基金 、国家百千万人才工程、有突出贡献中青年专家、南粤百杰等。
讲授课程
肿瘤生物学；大学生物学
学术成就
长期从事肿瘤生物学领域的研究，系统阐述了非编码 RNA与蛋白质的互作网络及生物学功能，揭示了调控肝癌生长转移的新机制，发现肝癌早期检测及精准治疗新策略。
作为通讯作者在Lancet Oncol、J Hepatol、Hepatology、Cancer Res、Nucleic Acids Res等国际知名杂志发表一系列高水平研究论文，包括多篇ESI高被引论文、杂志封面论文、专家同期评述论文。连续多年入选 “中国高被引学者”榜单。
作为第一发明人获授权中国发明专利15项，其中3项已转让，正在开展肝癌诊断试剂盒的研发。
作为第二完成人获2014年度国家自然科学奖二等奖；作为第一完成人获得教育部和广东省自然科学奖一等奖。
承担课题
先后主持国家自然科学基金委杰出青年科学基金、重点项目、集成项目及面上项目，科技部973、863及重点研发计划课题，广东省自然科学基金重点和面上项目、广州市科技计划项目重点专题等。
论文专著
Selected 25 publications (#为第一作者，*为通讯作者)
1. J Cheng, DH Huo, DM Kuang, J Yang, L Zheng*, SM Zhuang*. Human macrophages promote the motility and invasiveness of osteopontin- knockdown tumor cells. Cancer Res 67(11):5141-7, 2007.
2. DM Kuang, Y Wu, N Chen, J Cheng, SM Zhuang*, L Zheng*. Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes. Blood 110(2):587-95, 2007.
3. H Su, JR Yang, T Xu, J Huang, L Xu, Y Yuan*, SM Zhuang*. MicroRNA-101, downregulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity. Cancer Res 69(3):1135-42, 2009. (Highly Cited Papers based on ESI)
4. T Xu#, Y Zhu#, Y Xiong, YY Ge, JP Yun, SM Zhuang*. MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. Hepatology 50(1):113-21, 2009. (Highly Cited Papers based on ESI, Recommended Article by the Faculty of 1000 Biology)
5. Y Xiong#, JH Fang#, JP Yun, J Yang, Y Zhang, WH Jia, SM Zhuang*. Effects of microRNA-29 on apoptosis, tumorigenicity and prognosis of hepatocellular carcinoma. Hepatology 51(3): 836-45, 2010. (Highly Cited Papers based on ESI)
6. C Zeng, R Wang, D Li, XJ Lin, QK Wei, Y Yuan, Q Wang, W Chen, SM Zhuang*. A novel GSK-3β-C/EBPα-miR-122-Insuline-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma. Hepatology 52(5):1702-12, 2010. (Recommended Article by the Faculty of 1000 Biology)
7. J Luo, J Yang, B-Y Yu, W Liu, M Li, SM Zhuang*. Identification of Siah-interacting protein as a potential regulator of apoptosis and curcumin resistance. Oncogene 29(48):6357–66, 2010.
8. JH Fang, HC Zhou, C Zeng, J Yang, Y Liu, X Huang, JP Zhang, XY Guan, SM Zhuang*. MicroRNA-29b suppresses tumor angiogenesis, invasion and metastasis by regulating MMP-2 expression. Hepatology 54(5):1729-40, 2011. (Highly Cited Papers based on ESI)
9. Y Zhu#, Y Lu#, Q Zhang, JJ Liu, TJ Li, JR Yang, C Zeng, SM Zhuang*. MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. Nucleic Acids Res 40(10):4615-25, 2012.
10. J Gong#, JP Zhang#, BK Li, CX Zeng, KYou, MX Chen, Y Yuan*, SM Zhuang*. MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R. Oncogene 32(25):3071-9, 2013.
11. R Wang, N Zhao, S Li, JH Fang, MX Chen, J Yang, WH Jia, Y Yuan*, SM Zhuang*. MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2 and CDC42. Hepatology 58(2):642-53, 2013.
12. JP Zhang#, C Zeng#, L Xu#, J Gong, JH Fang, SM Zhuang.* MicroRNA-148a suppresses the epithelial-mesenchymal transition and metastasis of hepatoma cells by targeting Met/Snail signaling. Oncogene 33(31):4069-76, 2014.
13. N Zhao#, R Wang#, L Zhou, Y Zhu, J Gong, SM Zhuang*. MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3. Mol Cancer 13(1):35, 2014.
14. JJ Liu#, XJ Lin#, X Yang, L Zhou, S He, SM Zhuang*, J Yang*. A novel AP-1/miR-101 regulatory feedback loop and its implication in the migration and invasion of hepatoma cells. Nucleic Acids Res 42(19):12041-51, 2014.
15. JH Fang#, HC Zhou#, C Zhang, LR Shang, L Zhang, J Xu, L Zheng, Y Yuan, RP Guo, WH Jia, JP Yun, MS Chen, Y Zhang, SM Zhuang*. A novel vascular pattern promotes metastasis of hepatocellular carcinoma in an EMT-independent manner. Hepatology 62(2):452-65, 2015. (Cover story, Highlights, Editorials)
16. XJ Lin#, Y Chong#, ZW Guo#, C Xie, XJ Yang, Q Zhang, SP Li, Y Xiong, Y Yuan, J Min, WH Jia, Y Jie, MS Chen, MX Chen, JH Fang, C Zeng, Y Zhang, RP Guo, Y Wu, G Lin, L Zheng, SM Zhuang*. A serum-microRNA classifier for the early detection of hepatocellular carcinoma: a multicenter, retrospective, longitudinal biomarker identification study with a nested case-control study. Lancet Oncol 16(7):804-15, 2015. (Editorials)
17. HC Zhou#, JH Fang#, LR Shang, ZJ Zhang, Y Sang, L Xu, Y Yuan, MS Chen, L Zheng, Y Zhang, SM Zhuang*. MicroRNA-125b and microRNA-100 suppress metastasis of hepatocellular carcinoma by disrupting the formation of vessels that encapsulated tumour clusters. J Pathol 240(4):450-60, 2016.
18. JH Fang*, ZJ Zhang, LR Shang, YW Luo, Y Lin, Y Yuan*, SM Zhuang*. Hepatoma cell-secreted exosomal microRNA-103 increases vascular permeability and promotes metastasis by targeting junction proteins. Hepatology 68(4):1459-75, 2018. (Highlights, Highly Cited Papers based on ESI)
19. JH Fang #, L Xu #, LR Shang #, CZ Pan, J Ding, YQ Tang, H Liu, CX Liu, JL Zheng, YJ Zhang, ZG Zhou, J Xu, L Zheng, MS Chen*, SM Zhuang*. Vessels that encapsulate tumor clusters (VETC) pattern is a predictor of sorafenib benefit in patients with hepatocellular carcinoma. Hepatology 70(3):824-39, 2019. (Cover story)
20. YL Wang#, JY Liu#, JE Yang#, XM Yu, ZL Chen, YJ Chen, M Kuang, Y Zhu*, SM Zhuang*. Lnc-UCID promotes G1/S transition and hepatoma growth by preventing DHX9-mediated CDK6 downregulation. Hepatology 70(1):259-75, 2019. (Highly Cited Papers based on ESI)
21. C Xie, LZ Zhang, ZL Chen, WJ Zhong, JH Fang, Y Zhu, MH Xiao, ZW Guo, N Zhao, X He, SM Zhuang*. A hMTR4-PDIA3P1-miR-125/124-TRAF6 Regulatory Axis and Its Function in NF kappa B Signaling and Chemoresistance. Hepatology 71(5): 1660-77, 2020.
22. LZ Zhang#, JE Yang#, YW Luo, FT Liu, YF Yuan, SM Zhuang*. A p53/lnc-lp53 negative feedback loop regulates tumor growth and chemoresistance. Adv Sci 7(21):2001364, 2020.
23. SY Li, Y Zhu, RN Li, JH Huang, K You, YF Yuan*, SM Zhuang*, LncRNA lnc-APUE is repressed by HNF4α and promotes G1/S transition and hepatoma growth by regulating miR-20b/E2F1 axis. Adv Sci 8(7):2003094, 2021.
24. HC Zhou, CX Liu, WD Pan, LR Shang, JL Zheng, BY Huang, JY Chen, Ln Zheng, JH Fang*, SM Zhuang*. Dual and opposing roles of the androgen receptor in VETC-dependent and invasion-dependent metastasis of hepatocellular carcinoma. J Hepatol 75(4):900-11, 2021. (Editorials)
25. MZ Wu, YC Yuan, BY Huang, JX Chen, BK Li, JH Fang*, SM Zhuang*. Identification of a TGF-β/SMAD/lnc-UTGF positive feedback loop and its role in hepatoma metastasis. Signal Transduct Target Ther 6(1):395,2021.
