性别:女
工作电话:39332987
职称:教授
学历: 博士
个人主页: Profwensheng Lis homepage
电子邮件:[email protected]
导师类型: 博士生导师
学科方向:071002-动物学
071004-水生生物学
0860-生物与医药
研究方向
鱼类生长代谢与免疫的调控机制研究，功能基因产品的研究与开发
个人经历
李文笙，赌博app-网络赌博软件 教授、博士生导师。现任广东省重要经济鱼类健康养殖工程技术研究中心主任，中国水产学会水产生物技术专业委员会委员，淡水鱼类资源与生殖发育教育部重点实验室学术委员会委员等。1998年12月毕业于中山大学获理学博士学位，先后前往香港大学和美国国立健康研究院（NIH）从事博士后研究和做访问学者，2006年12月晋升为赌博app-网络赌博软件 教授。先后入选教育部“新世纪优秀人才”和广东省第五批高校“千百十工程”省级培养对象；获中国青年女科学家奖提名奖、广东省丁颖科技奖、广东省“三八红旗手标兵”称号、广东首届“自主创新十大女杰”；被评为“全国农业科研杰出人才”，其团队获“重要经济鱼类健康养殖综合技术研发创新团队”。
讲授课程
本科生课程：生理学（必修课），动物资源与利用（专选课）
研究生课程：鱼类生理学，动物遗传工程与应用，比较生理学
学术成就
李文笙教授长期从事鱼类生理学和分子生物学，神经内分泌和比较内分泌等相关领域的教学和研究工作。先后主持“863”、“973”、国家自然科学基金等多项国家和省部级科研项目，2008年至今担任农业农村部现代农业产业技术体系岗位科学家。多年来通过对鱼类生长和繁殖、摄食代谢和免疫等的调控机制进行系统研究，阐明了多种神经内分泌因子对鱼类生长、摄食、代谢和免疫的调控机理。先后获得教育部的高等学校科学技术进步奖（一等奖）（排名第一），广东省科学技术进步奖（一等奖）（排名第一）和教育部提名国家自然科学奖（一等奖）（排名第二）。在本领域重要学术期刊上发表100余篇文章，其中SCI收录论文超过60篇，他引400余次。获得15项国家发明专利授权（第一发明人）。
承担课题
近10年承担的主要课题：
- 国家特色淡水鱼现代产业技术体系（现代农业产业技术体系专项资金资助，2008-2025）
- 血红素-HO通路在亚硝酸盐胁迫导致的罗非鱼链球菌易感性的机制研究（国家自然科学基金项目，2021-01/2024-12）
- 促进水产养殖动物健康生长的生物产品开发与应用技术研究 （横向课题，2020-1/2022-12）
- 鱼类生长的遗传基础与调控机理研究（国家重点研发计划“蓝色粮仓科技创新”专项，2018-12/2022-12）
- 广东重要养殖鱼类生长促进剂的开发与应用技术研究（广东省海洋与渔业局海港建设和渔业产业专项，2016-06/2018-12）
- 现代农业人才支撑计划项目（农业农村部，2016-01/2020-12）
- 赤点石斑鱼（Epinephelus akaara）几丁质酶重组蛋白及其相关生物工程产品的制备和应用（广东省科技计划项目，2015-10/2018-10）
- 神经内分泌因子生长抑素调控硬骨鱼类生长和糖脂代谢的协同机制研究（国家自然科学基金项目，2015-1/2018-12）
- 鱼类新型细胞因子Adiponectin和受体的分子克隆及其对糖脂代谢的调控机制 （国家自然科学基金项目，2013-1/2016-12）
- 石斑鱼新型摄食因子的克隆鉴定及其对肌肉糖代谢的调控（国家自然科学基金项目，2011-1/2013-12）
- 鱼类生长基因调控网络和分子设计育种的基础研究（科技部973项目子课题，2010-1/2014-12）
论文专著
近10年发表的主要文章：
Zongzhen Liao, Dihang Lin, Jirong Jia, Ran Cai, Yang Yu and Wensheng Li *2021 Innate Immune Response to Fasting and Refeeding in the Zebrafish Kidney.Biomolecules 2021, 11（6）, 825. //doi.org/10.3390/biom11060825
Xiaozheng Yu, Ying Xin, Lili Cui，Jirong Jia, Xi Yuan,Shiwei Fu, Jiahui Zhang, Caiyun Sun, Xiangjun Miao, Wensheng Li* 2021 Effects of neuropeptide Y as a feed additive on stimulating the growth of tilapia (Oreochromis niloticus) fed low fish meal diets. Peptides 138 (4), 170505 //doi.org/10.1016/j.peptides.2021.170505
Xi Yuan, Yuxin Lin, Jingkai Qin, Yazhou Zhang, Guokun Yang, Ruijian Cai, Zongzhen Liao, Caiyun Sun, Wensheng Li* 2020 Molecular identification, tissue distribution and in vitro functional analysis of growth hormone and its receptors in red-spotted grouper (Epinephelus akaara). Comparative Biochemistry and Physiology, Part B。250（2020）110488 //doi.org/10.1016/j.cbpb.2020
蔡 然， 陈立敏， 辛 颖， 赵早亚， 俞筱筝，黄金凤， 廖宗甄， 李文笙* 2020 盐度胁迫对尼罗罗非鱼免疫相关指标的影响。 水产学报, 44(6): 978−986
Zaoya Zhao, Caiyun Sun, Limin Chen, Jingkai Qin, Xi Yuan, Wensheng Li* 2020 Inorganic nitrite increases the susceptibility of tilapia (Oreochromis niloticus) leucocytes to Streptococcus agalactiae. Fish and Shellfish Immunology 97(2020)1-11 ( //doi.org/10.1016/j.fsi.2019.12.039)
Jingkai Qin, Xi Yuan, Chenguang Liu, Jirong Jia, Yazhou Zhang, Wensheng Li* 2020 Development of a time-resolved fluoroimmunoassay for measuring plasma growth hormone in Nile tilapia (Oreochromis niloticus). General and Comparative Endocrinology 287（2020）11357 ( //doi.org/10.1016/j.ygcen.2019.11357)
Jirong Jia※, Jingkai Qin※, Xi Yuan, Zongzhen Liao, Jinfeng Huang, Bin Wang, Caiyun Sun, Wensheng Li* 2019 Microarray and metabolome analysis of hepatic response to fasting and subsequent refeeding in zebrafish ( Danio rerio). BMC Genomics （2019）20：919 //doi.org/10.1186/s12864-019-6309-6
Zaoya Zhao, Xiaozheng Yu, Jirong Jia, Guokun Yang, Caiyun Sun and Wensheng Li* 2019 miR-181b-5p May Regulate Muscle Growth in Tilapia by Targeting Myostatin b Frontiers in Endocrinology 2019 doi: 10.3389/fendo.2019.00812
Guokun Yang, Beichen Chen, Caiyun Sun, Xi Yuan, Yazhou Zhang, Jingkai Qin, Wensheng Li* 2019 Molecular identification of grouper Igfbp1 and its mRNA expression in primary hepatocytes under Gh and Insulin General and Comparative Endocrinology 281（2019）137-144
Yazhou Zhang, Zimu Tang, Weiru Lin, Xi Yuan, Jirong Jia, Caiyun Sun, Wensheng Li⁎ 2019 Molecular identification, tissue distribution and functional analysis of
somatostatin receptors (SSTRs) in red-spotted grouper (Epinephelus akaara).General and Comparative Endocrinology 274 (2019) 87–96
Guokun Yang, Qinqin Song, Caiyun Sun, Jingkai Qin, Jirong Jia, Xi Yuan,Yazhou Zhang, Wensheng Li 2018 Ctrp9 and adiponectin receptors in Nile tilapia (Oreochromis niloticus): Molecular cloning, tissue distribution and effects on reproductive genes.General and Comparative Endocrinology 2018（265）160-173
Wenbo Chen, Haoran Lin#, Wensheng Li# 2018 Molecular cloning and expression profiles of IGFBP-1a in Common carp (Cyprinus carpio) and its expression regulation by growth hormone in hepatocytes. Comparative Biochemistry and Physiology, Part B 221–222 (2018) 50–59
Jirong Jia; Yazhou Zhang; Xi Yuan; Jingkai Qin; Guokun Yang; Xiaozheng Yu; Bin Wang; Caiyun Sun; Wensheng Li* 2018 Reactive oxygen species participate in liver function recovery during compensatory growth in zebrafish (Danio rerio).Biochemical and Biophysical Research Communications.499 : 285-290
Guokun Yang, Chaobin Qin†, Bin Wang‡, Jirong Jia, Xi Yuan, Caiyun Sun and Wensheng Li* 2017 Molecular identification and functional analysis of Ctrp9 in Epinephelus coioides. Journal of Molecular Endocrinology (2017) 58, 179–191
Dongfang Wang, Jingkai Qin, Jirong Jia, Peipei Yan, Wensheng Li* 2017 Pou1f1, the Key Transcription Factor Related to Somatic Growth in Tilapia (Orechromis niloticus), Is Regulated by Two Independent Post-Transcriptional Regulation Mechanisms Biochemical and Biophysical Research Communications.483(2017)559-565
Peipei Yan, Jirong Jia, Guokun Yang, Dongfang Wang, Caiyun Sun, Wensheng Li* 2017 Duplication of neuropeptide Y and peptide YY in Nile tilapia Oreochromis niloticus and their roles in food intake regulation.Peptides 88 (2017) 97–105
闫培培，李文笙 2017 神经肽Y系统在硬骨鱼类摄食调控中的作用的研究进展。中国水产科学.24(1):199-207
李文笙*，王东方 2017 microRNA在鱼类中研究进展。水产学报.41(4)628-639
Cong Zhang, Caiyun Sun, Bin Wang, Peipei Yan, Amin Wu, Guokun Yang, Wensheng Li* 2016 Orexin-A stimulates the expression of GLUT4 in a glucose dependent manner in the liver of orange-spotted grouper (Epinephelus coioides).Comparative Biochemistry and Physiology, Part A (2016), pp. 95-104
Bin Wang, Jirong Jia, Guokun Yang, Jingkai Qin, Cong Zhang, Qiuping Zhang, Caiyun Sun, Wensheng Li* 2016 In vitro effects of somatostatin on the growth hormone-insulin-like growth factor axis in orange-spotted grouper (Epinephelus coioides).General and Comparative Endocrinology. 237 (2016) 1–9
王滨，李文笙 2015 Neuronostatin的发现及其生理学功能的研究进展。生理科学进展 46（6）449-452
林建升， 张秋平， 李文笙* 2015 不同养殖模式下尼罗罗非鱼消化酶活性的比较. 水产学报 39(1),65-74
Fei Wang,Weimin Chen,Haoran Lin,Wensheng Li* 2014 Cloning, expression, and ligand-binding characterization of two neuropeptide Y receptor subtypes in orange-spotted grouper, Epinephelus coioides.Fish Physiology and Biochemistry.Fish Physiol Biochem. 2014 Dec;40(6):1693-707
Lu Yang, Caiyun Sun,, Wensheng Li * 2014 Neuropeptide B in Nile tilapia Oreochromis niloticus: Molecular cloning and its effects on the regulation of food intake and mRNA expression of growth hormone and prolactin. General and Comparative Endocrinology. 200 (2014) 27–34
Chaobin Qin, Bin Wang, Caiyun Sun, Jirong Jia and Wensheng Li* 2014 Orange-spotted grouper (Epinephelus coioides) adiponectin receptors: molecular characterization, mRNA expression, and subcellular location. General and Comparative Endocrinology 198 (2014) 47-58
Bin Wang, Chaobin Qin, Cong Zhang, Jirong Jia, Caiyun Sun, Wensheng Li *2014 Differential involvement of signaling pathways in the regulation of growth hormone release by somatostatin and growth hormone-releasing hormone in orange-spotted grouper (Epinephelus coioides).Molecular and Cellular Endocrinology 382 (2014) 851–859
Caiyun Sun, Da Duan , Bo Li, Chaobin Qin, Jirong Jia, Bin Wang, Haiyan Dong, Wensheng Li* 2014 UII and UT in grouper: cloning and effects on transcription of hormones related to growth control.Journal of Endocrinology(2014) 220, 35–48
李文笙，王滨 2013 鱼类生长抑素调控垂体生长激素分泌的作用机制. 水产学报.37(12)143-152
Tang Z, Sun C, Yan A, Wu S, Qin C, Zhang Y, Li W*. 2013 Genes involved in fatty acid metabolism: Molecular characterization and hypothalamic mRNA response to energy status and neuropeptide Y treatment in the orange-spotted grouper Epinephelus coioides. Mol Cell Endocrinol. 376(1-2):114-124.
Wu, S., Li, B., Lin, H., Li, W*.,2012 Stimulatory effects of neuropeptide Y on the growth of orange-spotted grouper (Epinephelus coioides).General and Comparative Endocrinology 179 (2012) 159–166
Wenbo Chen , Haoran Lin ,Wensheng Li.2012 Molecular characterization and expression pattern of insulin-like 1growth factor binding protein-3 (IGFBP-3) in common carp, Cyprinus carpio.Fish Physiol Biochem.(2012) 38:1843–1854
Jun Chen, Yanhong Zhang, Zhiguo Tanga, Jiewei Mao, Zhonglei Kuang, Chaobin Qin, Wensheng Li*.2012 Production of recombinant orange-spotted grouper (Epinephelus coioides) follicle-stimulating hormone (FSH) in single-chain form and dimer form by Pichia
pastoris and their biological activities. Gen.Comp. Endocrinol. 178 (2012) 237–249
Yuehua Qian, Aifen Yan, Haoran Lin, Wensheng Li.2012 Molecular characterization of the GHRH/GHRH-R and its effect on GH synthesis and releasein orange-spotted grouper (Epinephelus coioide).Comparative Biochemistry and Physiology, Part B163(2012)229–237
Yangyuan Li , Shuge Wu, Jing Ouyang , Limin Mao, Wensheng Li,⇑, Haoran Lin.2012 Expression of insulin-like growth factor-1 of orange-spotted grouper (Epinephelus coioides) in yeast Pichia pastoris. Protein Expression and Purification 84 (2012) 80–85
Zhang Y, Feng Shaozhen, Chen Jun, Qin Chaobin, Lin Haoran, Li Wensheng (2012) Stimulatory effects of chitinase on growth and immune defense of orange-spotted grouper (Epinephelus coioides), Fish & Shellfish Immunology 32(2012) 844-854
