性别:男
电子邮件:[email protected]
导师类型: 博士生导师
工作电话:020-84110778
职称: 教授
学历: 博士研究生
学科方向: 071005-微生物学
0860-生物与医药

 

研究方向

病原细菌/人体微生物组与宿主互作; 益生菌资源挖掘及其改善疾病的分子机制

         微生物与人类宿主之间的相互作用是生物物种间最复杂的相互作用之一。一方面，在与人类宿主亿万年共同进化的过程中，共栖微生物群（Commensal）形成了独特的微生态系统，成功适应了宿主环境。另一方面，外源性的病原菌（Pathogens）或共栖有害微生物则能突破宿主的免疫屏障，实现感染。肠道菌群是肠道内寄居的种类繁多的微生物的总称。鉴于人体胃肠道微生物群细胞的总数是人体细胞总数的数倍，编码的基因数量可达人体自身基因数量的150倍，因此被称为“人体第二基因组”和“新器官”。人体胃肠道微生态系统是人体代谢的重要参与者，代谢产生的短链脂肪酸等促进肠道上皮细胞生长与分化；肠道菌群之间可以通过如分泌系统分泌的效应蛋白等维持菌群的平衡。肠道菌群平衡的失调（Dysbiosis）与约90%的人类疾病密切相关，包括胃肠道疾病、炎症、代谢障碍类疾病（如肥胖、糖尿病等）、心血管疾病、免疫疾病、癌症和精神性疾病等。对肠道微生物组与疾病关系的研究，将为开发基于微生物的疾病诊断、疾病干预、治疗和益生菌产品的研发等奠定基础。目前该领域的研究正从微生物与宿主互作的“关联性”向“因果性”转变。本实验室围绕微生物组（Microbiome，包括微生物及其代谢产物及肠道自身代谢物）与宿主相互作用的机制，开展如下研究：

（1）肠道微生物组与宿主的互作及其分子机制：我们综合运用基因组学、代谢组学、基因组操作和生物信息学等技术，研究肠道微生物组或肠道细菌与炎症、肥胖症和癌症等的发生、发展的关联性及其分子机制；发现生物标志物（biomarker）及可成药靶点（druggable targets)。

（2）肠道微生物培养组学及益生菌资源挖掘与应用: 运用培养组学策略分离纯化各类肠道益生菌，并评估其临床应用价值；开展临床干预实验，研究其益生的分子机制。

（3）肠道微生物的基因组遗传操作：为治疗性工程化微生物活菌药物设计及肠菌的精准编辑奠定基础。

（4）靶向抗菌药物筛选及作用机理：以细菌分泌的效应蛋白作为靶位点，筛选活性先导物，获得避免耐药性产生的新型抗生素：结核分枝杆菌（Mycobacterium tuberculosis, Mtb）是结核病的病原，感染了我国近三分之一的人口，是国人健康的重大威胁，急需新的抗结核药物。我们以结核分枝杆菌关键效应蛋白为靶点，建立相应的筛选系统，从微生物代谢产物中筛选效应蛋白的抑制剂，并研究其作用机制，期望获得新型的、能避免耐药性产生的抗结核药物。

        本实验室位于环境优雅的中⼭大学南校区赌博app 曾宪梓堂北院112-114室，在中⼭大学赌博app 微生物学方向招收专职科研人员、博士后、博士生和硕士生。我们实验室是一个积极进取、开放、团结活泼并鼓励合作和创新的科研团队。欢迎对我们实验室的研究方向感兴趣、对科学研究有热情、具有主动精神、勇于挑战、努力刻苦和善于合作的学生加入，共同投身于造福人类的崇高事业。我们也欢迎本科学生加⼊我们团队。

 

讲授课程

1. 主讲本科生课程：必修课“生物技术学”

2. 主讲本科生课程：必修课“生物技术综合实验”

 

 

 

论文专著

一、部分论文（2009--）

  1. Zhenhuang Ge, Chun Chen, Junyi Chen, Zhou Jiang, Lingming Chen, Yingqi Wei, Haiyang Chen, Lei He, Yi Zou, Xiaoxuan Long, Hongyu Zhan, Huaiming Wang,* Hui Wang,* and Yongjun Lu*. Gut Microbiota-Derived 3-Hydroxybutyrate Blocks GPR43-Mediated IL6 Signaling to Ameliorate Radiation Proctopathy. Advanced Science, 2024 May 14:e2306217.
  2. Jiewen Chen#, Xiyuan Liu#, Junli Gong, Xiaorong Lin, Hongyan Huang, Jianli Zhao, Phei Er Saw, Yongjun Lu*, Hai Hu*, Erwei Song*. High-fat diet promotes cancer progression by inducing gut microbiota-mediated leucine production and MDSC differentiation. PNAS, 2024, 121(20), e2306776121.
  3. Shihao Cheng,#, Yi Zou,#, Xi Chen, Jiahao Chen, Bin Wang, Jinying Tian, Fei Ye, Yu Lu, Haihong Huang,*, Yongjun Lu,*, Dongfeng Zhang,*. Design, synthesis and biological evaluation of 3-substituted-2-thioxothiazolidin-4- one (rhodanine) derivatives as antitubercular agents against Mycobacterium tuberculosis protein tyrosine phosphatase B. European Journal of Medicinal Chemistry, 2023, Oct 5; 258:115571. 
  4. Gong, J., Liu, S., Wang, S., Ruan, H., Mou, Q., Fan, P., Chen, T., Cai, W., Lu, Y*., & Lu, Z*.. Identification of fecal microbiome signatures associated with familial longevity and candidate metabolites for healthy aging. Aging Cell, 2023, 22(6): e13848.
  5. Shihao Cheng, Qinglin Wang, Xi Chen, Jiahao Chen, Bin Wang, Dongni Chen, Dong Shen, Jinying Tian, Fei Ye, Yu Lu, Haihong Huang*, Yongjun Lu*, Dongfeng Zhang*. Discovery of biphenyls bearing thiobarbiturate fragment by structure-based strategy as Mycobacterium tuberculosis protein tyrosine phosphatase B inhibitors. Bioorganic & Medicinal Chemistry, 2022, Nov 1;73:117006.
  6. Zhenhuang Ge, Zhiqi Kuang, Jiahao Chen, Junyi Chen, Tianhao Liu, Zhigang She and Yongjun Lu*.Comparative genomics analysis of Bacillus velezensis LOH112 isolated from a nonagenarian provides insights into its biocontrol and probiotic traits. Gene, 2022, //doi.org/10.1016/j.gene.2022.146644.
  7. Zhenhuang Ge, Peibo Yuan, Lingming Chen, Junyi Chen, Dong Shen, Zhigang She and Yongjun Lu*. New global insights on the regulation of the biphasic life cycle and virulence via ClpP-dependent proteolysis in Legionella pneumophila. Molecular & Cellular Proteomics, 2022,21(5):100233. doi: //doi.org/10.1016/j.mcpro.2022.100233.
  8. Lina Xiong, Mingchen Xia, Qinglin Wang, Zhen Meng, Jie Zhang, Guohui Yu, Zhangyong Dong, Yongjun Lu, Yunhao Sun. DNA aptamers specific for Legionella pneumophila: systematic evolution of ligands by exponential enrichment in whole bacterial cells. Biotechnology Letters, 2022, //doi.org/10.1007/s10529-022-03252-z. 
  9. Yong Rao†, *, Zhiqi Kuang† , Chan Li, Shiyao Guo, Yaohao Xu, Dandan Zhao, Yutao Hu, Bingbing Song, Zhi Jiang, Zhenhuang Ge, Xiyuan Liu, Chengdao Li, Shuobin Chen, Jiming Ye, Zhishu Huang*, Yongjun Lu*. Gut Akkermansia muciniphila ameliorates metabolic-dysfunction associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis. Gut Microbes, 2021, 13(1), e1927633.
  10. Hui-Yun Huang, Jia-Hua Huang, Yong-Heng Wang, Dan Hu, Yong-jun Lu, Zhi-Gang She, Guo-Dong Chen, Xin-Sheng Yao, Hao Gao. The oxidation cascade of a rare multifunctional P450 enzyme involved in Asperterpenoid A biosynthesis. Frontiers in Chemistry, 2021,16 December, //doi.org/10.3389/ fchem.2021.785431
  11. Wei Cai, Xiaodong Chen, Xuejiao Men, Hengfang Ruan, Mengyan Hu, Sanxin Liu, Tingting Lu , Jinchi Liao , Bingjun Zhang , Danli Lu , Yinong Huang , Ping Fan , Junping Rao , Chunyan Lei, Jihui Wang, Xiaomeng Ma, Qiang Zhu, Lili Li, Xiuyun Zhu, Yujiao Hou, Shu Li, Qing Dong, Qing Tian, Lulu Ai, Wenjing Luo, Mengyun Zuo, Liping Shen, Congyan Xie, Hongzhong Song, Ganlin Xu, Kangdi Zheng, Zhao Zhang, Yongjun Lu, Wei Qiu, Tao Chen, Andy Peng Xiang, Zhengqi Lu. Gut microbiota from patients with arteriosclerotic CSVD induces higher IL-17A production in neutrophils viaactivating RORγt. Science Advances, 2021, Jan 22;7(4):eabe4827. doi: 10.1126/sciadv.abe4827.
  12.  Ze'en Xiao, Shao'e Lin, Zhigang She, Yongjun Lu, Zhen Tan, Yonghong Liu. A new anthraquinone from mangrove endophytic fungus Aspergillus sp. 16-5C. Natural Product Research, 2021 Nov 10;1-6. doi: 10.1080/14786419.2021.2001810. 
  13. Dongni Chen, Lan Liu, Yongjun Lu, Senhua Chen. Identification of fusarielin M as a novel inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB). Bioorganic Chemistry, 2021,Jan, 106:104495.  
  14. 王庆琳，陈水浩，陈冬妮，刘岚，佘志刚，陆勇军*. 南海海洋真菌资源及其活性次级代谢产物研究评述。生物资源，2020，42(5):505 ~ 514.(特约综述）
  15. Chen Jie-wen, Liu Xi-yuan, Huang Hong-yan, Zhang Fang-fang, Lu Yong-jun, Hu Hai*. High salt diet may promote progression of breast tumor through eliciting immune response. International Immunopharmacology, 2020, July, 25;87:106816.
  16. Yuan PB, He L, Chen DN, Sun YH, Ge ZH, Shen D, Lu YJ*. Proteomic characterization of Mycobacterium tuberculosisreveals potential targets of bostrycin. Journal of Proteomics. 2020, Feb 10. 212:103576. doi: 10.1016/j.jprot.2019.103576.
  17. Zhaoming Liu, Qinglin Wang, Saini Li, Hui Cui, Zhanghua Sun, Dongni Chen, Yongjun Lu,* Hongxin Liu,* and Weimin Zhang*.  Polypropionate Derivatives with Mycobacterium tuberculosis Protein Tyrosine Phosphatase B Inhibitory Activities from the Deep-Sea- Derived Fungus Aspergillus   fischeri FS452. Journal of Natural Products, 2019, 82 (12):3440-3449, Dec 27. DOI: 10.1021/acs.jnatprod.9b00834.
  18.  Zhen-huang Ge, Qin-sha Long, Pei-bo Yuan, Xin Pan, Dong Shen and Yong-jun Lu*. The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle of Legionella pneumophila. Frontiers in Microbiology, 2019, Nov.7,10:2495. doi: 10.3389/fmicb.2019.02495.
  19. Qin Zeng, Junli Gong, Xiyuan Liu, Chen Chen, Xiaobo Sun, Huijuan Li, Yifan Zhou, ChunPing Cui, Yuge Wang, Yu Yang, Aimin Wu, Yaqing Shu, Xueqiang Hu, Zhengqi Lu, Song Guo Zheng*, Wei Qiu*, Yongjun Lu*. Gut dysbiosis and lack of short chain fatty acids in a Chinese cohort of patients with multiple sclerosis. Neurochemistry International, 2019(129)104468.
  20. He L, Lin Y, Ge ZH, He SY, Zhao BB, Shen D, He JG, Lu YJ*. The Legionella pneumophila effector WipA disrupts host F-actin polymerisation by hijacking phosphotyrosine signaling. Cellular Microbiology. 2019 Jun, 21(6):e13014. doi: 10.1111/cmi.13014. 
  21. Dongfeng Zhang, Yun Lin, Xi Chen, Wenting Zhao, Dongni Chen, Meng Gao, Qinglin Wang, Bin Wang, Haihong Huang⁎, Yongjun Lu⁎, Yu Lu⁎. Docking- and pharmacophore-based virtual screening for the identification of novel Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with a thiobarbiturate scaffold. Bioorganic Chemistry, 2019, 85: 229–239.
  22. Jia-Hua Huang, Jian-Ming Lv, Qiao-Zhen Wang, Jian Zou, Yong-Jun Lu, Qing-Lin Wang, Dong-Ni Chen, Xin-Sheng Yao, Hao Gao and Dan Hu. Biosynthesis of an anti-tuberculosis sesterterpenoid asperterpenoid A. Organic & Biomolecular Chemistry, 2019 Jan 2; 17(2):248-251.
  23. LUO X-W, LIN Y, LU Y-J, Zhou XF, Liu YH. Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008 [J]. Chinese Journal of Natural Medicines, 2019, 17(2): 149-154.
  24. Sun yunhao, Li Pai, Shen Dong, Wei Qiaoling, He Jianguo, Lu Yongjun*. The Ralstonia solanacearum effector RipN suppresses plant PAMP-triggered immunity, localizes to the endoplasmic reticulum and nucleus, and alters the NADH/NAD+ ratio in Arabidopsis. Molecular Plant Pathology. 2019, 20(4):533-546. First published, 2018, Nov 30. doi: 10.1111/mpp.12773.
  25. Gong JL, Qiu W, Zeng Q, Liu XY, Sun XB, Li HJ, Yang Y, Wu AM, Bao J, Wang YG, Shu YQ, Hu XQ, Bellanti JA, Zheng SG, Lu YJ*, Lu ZQ*. Lack of short-chain fatty acids and overgrowth of opportunistic pathogens define dysbiosis of neuromyelitis optica spectrum disorders: A Chinese pilot study. Multiple Sclerosis Journal, 2018, Aug 16:1352458518790396.
  26. Yu Dai, Yun Lin, Xiaoyan Pang, Xiaowei Luo, Limbadri salendra, Junfeng Wang，Xuefeng Zhou, Yongjun Lu, Bin Yang, Yonghong Liu. Peptides from the Soft Coral-associated Fungus Simplicillium sp. SCSIO41209. Phytochemistry, 2018, 154:56–62.
  27. Qian Jia, Yun Lin, Xue-jing Gou, Lei He, Dong Shen, Dong-ni Chen, Wei Xie *, Yong-jun Lu*. Legionella pneumophilaeffector WipA, a bacterial PPP protein phosphatase with PTP activity. Acta Biochimica et Biophysica Sinica. 2018, 50(6):547-554.
  28. GONG Junli, SUN Xiaoming, LIN Zhiyong, LU Hongfeng, LU Yongjun. Geochemical and microbial characters of sediment from the gas hydrate area in the Taixinan Basin, South China Sea. Acta Oceanol. Sin., 2017, 36(9):52–64. 
  29. Senhua Chen, Meng Ding; Weiyang Liu; Xishan Huang, Zhaoming Liu, Yongjun Lu, Hongju Liu, Zhigang She. Anti-inflammatory Meroterpenoids from the Mangrove Endophytic Fungus Talaromyces amestolkiae YX1.Phytochemistry, 2017 Nov 30;146:8-15. 
  30. Hui Cui, Yun Lin, Mingchu Luo, Yongjun Lu, Xishan Huang, and Zhigang She. Diaporisoindoles A−C: Three Isoprenylisoindole Alkaloid Derivatives from the Mangrove Endophytic Fungus Diaporthe sp. SYSU-HQ3. Organic Letters, 2017, Oct 20;19(20):5621-5624.
  31. Qianqian Ji, Caiping Guo, Chen Xie, Yingdan Wu, Pei Zhang, Hui Li, Yongjun Lu*. Genetically engineered cell lines for a1-antitrypsin expression. Biotechnology Letters, 2017, 39:1471-1476.
  32. Senhua Chen, Liqing He, Dongni Chen, Runlin Cai, Yuhua，Long, Yongjun Lu* and Zhigang She*. Talaramide A, an Unusual Alkaloid from the Mangrove Endophytic Fungus Talaromyces sp. (HZ-YX1) as Inhibitor of Mycobacterial PknG. New Journal of Chemistry, 2017, 146:8-15.
  33. Liu Z, Chen S, Qiu P, Tan C, Long Y, Lu Y, She Z. (+)- and (-)-Ascomlactone A: a pair of novel dimeric polyketides from a mangrove endophytic fungus Ascomycota sp. SK2YWS-L. Organic & Biomolecular Chemistry. 2017, 15(48):10276-10280.
  34. Sun Yunhao, Li Pai, Deng Mengying, Shen Dong, Dai Guangyi, Yao Nan, Lu Yongjun*. The Ralstonia solanacearumeffector RipAK suppresses plant hypersensitive response by inhibiting the activity of host catalases.  Cellular Microbiology, 2017, 19: e12736. 
  35. Dongni Chen, Shuangshuang Ma, Lei He, Peibo Yuan, Zhigang She and Yongjun Lu*. Sclerotiorin inhibits protein kinase G from Mycobacterium tuberculosis and impairs mycobacterial growth in macrophages. Tuberculosis, 2017,103:37-43.
  36. Chunbin Tan, Zhaoming Liu, Senhua Chen, Xishan Huang, Hui Cui, Yuhua Long, Yongjun Lu and Zhigang She. Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L. Scientific report, 2016 Nov 4;6:36609. 
  37. Meng-ying Deng, Yun-hao Sun, Pai Li, Bei Fu, Dong Shen, Yong-jun Lu*. The phytopathogenic virulent effector protein RipI induces apoptosis in budding yeast Saccharomyces cerevisiae. Toxicon, 2016, 121:109-118.
  38. Bei-bei Zhao, Xiang-hui Li, Yong-lun Zeng and Yong-jun Lu*. ClpP-deletion impairs the virulence of Legionella pneumophila and the optimal translocation of effector proteins. BMC Microbiology, 2016, 16(1):174-185.
  39. Hui Cui, Yayue Liu, Yang Nie, Zhaoming Liu, Zhengrui Zhang, Yongjun Lu, Lei He, Xishan Huang *, Zhigang She*. Polyketides from the Mangrove-Derived Endophytic Fungus Nectria sp. HN001 and Their α-Glucosidase Inhibitory Activity. Marine Drugs, 2016, 14(5)：86. 
  40. Liu, Zhaoming; Chen, Yan; Chen, Senhua; Liu, Yayue; Lu, Yongjun; Chen, Dongni; Lin, Yongcheng; Huang, Xishan; She, Zhigang. Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010. Organic Letters, 2016, 18:1406-1409.
  41. Dong-ni Chen, Hong Chen, Zhi-gang She, Yong-jun Lu*. Identification of Bostrycin Derivatives on Inhibition of MptpB Phosphatase from Mycobacterium tuberculosis. Medicinal Chemistry, 2016;12(3):296-302.
  42.  Li J, Xue YY, Yuan J, Lu YJ, Zhu X, Lin YC, Liu L*. Lasiodiplodins from Mangrove Endophytic Fungus Lasiodiplodia sp. 318#. Natural Product Research, 2016, 30(7), 755-760.
  43. Senhua Chen, Zhaoming Liu, Hanxiang Li, Guoping Xia, Yongjun Lu, Lei He, Shaodong Huang, Zhigang She. β-Resorcylic acid derivatives with a-glucosidase inhibitory activity from Lasiodiplodia sp. ZJ-HQ1, an endophytic fungus in the medicinal plant Acanthus ilicifolius, Phytochem. Lett. 2015,13, 141–146.
  44. Senhua Chen, Zhaoming Liu, Yayue Liu, Yongjun Lu, Lei He, Zhigang She. New Depsidones and Isoindolones from the Mangrove Endophytic Fungus Meyerozyma guilliermondii (HZ-Y2) Isolated from the South China Sea, Beilstein J. Org. Chem. 2015,11,1187–1193.
  45. Liu Y, Yang Q, Xia G, Huang H, Li H, Ma L, Lu Y, He L, Xia X, She Z. Polyketides with α-Glucosidase Inhibitory Activity from a Mangrove Endophytic Fungus, Penicillium sp. HN29-3B1. J Nat Prod. 2015，78(8):1816-22.  
  46. He Lei, Deng Qing-li, Chen Mou-tong, Wu Qing-ping, Lu Yong-jun*. Proteomics analysis of Listeria monocytogenesATCC 19115 in response to simultaneous triple stresses. Archives of Microbiology, 2015, 197(6):833-841. 
  47. Yayue Liu, Senhua Chen, Zhaoming Liu, Yongjun Lu, Guoping Xia, Hongju Liu, Lei He and Zhigang She. Bioactive Metabolites from Mangrove Endophytic Fungus Aspergillus sp. 16-5B. Marine Drugs, 2015, 13: 3091-3102.
  48.  Ze'en Xiao, Shao'e Lin, Chunbin Tan, Yongjun Lu, Lei He, Xishan Huang, Zhigang She. Asperlones A and B, Dinaphthalenone Derivatives from a Mangrove Endophytic Fungus Aspergillus sp. 16-5C. Marine Drugs, 2015, 13: 366-378. 
  49. Sun Meng-yi, Lu Yong-jun*. A simple method for constructing magnetic Escherichia coli. BioRxiv, 2014, October 10, doi: //doi.org /10.1101/ 010249
  50. Yayue Liu, Guoping Xia, Hanxiang Li, Lin Ma, Bo Ding , Yongjun Lu , Lei He , Xuekui Xia *, Zhigang She*, Vermistatin Derivatives with α-Glucosidase Inhibitory Activity from the Mangrove Endophytic Fungus Penicillium sp. HN29-3B1. Planta Med., 2014, 80, 912-917. 
  51. Li Jing，Yang Xin, Lin Yingying, Yuan Jie, Lu Yongjun, Zhu Xun, Li Jun, Li Mengfeng, Lin Yongcheng, He Jianguo, Liu Lan. Meroterpenes and azaphilones from marine mangrove endophytic fungus Penicillium 303#. Fitoterapia, 2014, 97:241-246. 
  52. Guoping Xia, Jia Li, Hanxiang Li, Yuhua Long, Shao’e Lin, Yongjun Lu, Lei He, Yongcheng Lin, Lan Liu and Zhigang She. Alterporriol-Type Dimers from the Mangrove Endophytic Fungus, Alternaria sp. (SK11), and Their MptpB Inhibitions. Marine Drugs, 2014, 12：2953-2969.
  53. Li HX, Jiang J, Liu Z, Lin S, Xia G, Xia X, Ding B, He L, Lu Y*, She Z*. Peniphenones A-D from the Mangrove Fungus Penicillium dipodomyicola HN4-3A as Inhibitors of Mycobacterium tuberculosis Phosphatase MptpB. J Nat Prod. 2014,77(4): 800−806.
  54. Ding B, Yuan J, Huang X, Wen W, Zhu X, Liu Y, Li H, Lu Y, He L, Tan H, She Z. New dimeric members of the phomoxanthone family: phomolacton-exanthones A, B and deacetylphomoxanthone C isolated from the fungus Phomopsis sp. Marine Drugs. 2013 , 11(12):4961-72. 
  55. Du J, Xiao K, Li L, Ding X, Liu H, Lu Y, Zhou S. Temporal and spatial diversity of bacterial communities in coastal waters of the South china sea. PLoS One. 2013, 8(6):e66968.
  56. Xiao Z, Huang H, Shao C, Xia X, Ma L, Huang X, Lu Y, Lin Y, Long Y, She Z. Asperterpenols A and B, new sesterterpenoids isolated from a mangrove endophytic fungus Aspergillus sp. 085242. Organic Letters. 2013, 15(10):2522-5. 
  57. Du J, Li L, Ding X, Hu H, Lu Y, Zhou S. Isolation and characterization of a novel cyanophycin synthetase from a deep-sea sediment metagenomic library. Appl Microbiol Biotechnol. 2013, 97(19):8619-28. 
  58. Huang, Xishan; Huang, Hongbo; Li, Hanxiang; Sun, Xuefeng; Huang, Huarong; Lu, Yongjun; Lin, Yongcheng; Long, Yuhua*; She, Zhigang *. Asperterpenoid A, a New Sesterterpenoid as an Inhibitor of Mycobacterium tuberculosisProtein Tyrosine Phosphatase B from the Culture of Aspergillus sp. 16-5c. Organic Letters. 2013，15（4）：721-723. 
  59. Huang C, Jin H, Song B, Zhu X, Zhao H, Cai J, Lu Y, Chen B, Lin Y. The cytotoxicity and anticancer mechanisms of alterporriol L, a marine bianthraquinone, against MCF-7 human breast cancer cells. Appl Microbiol Biotechnol. 2012, 93(2):777-85.
  60. Ding X, Yin B, Qian L, Zeng Z, Yang Z, Li H, Lu Y, Zhou S. Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm. J Med Microbiol. 2011, 60(Pt 12):1827-34.
  61. Hanxiang Li, Hongbo Huang, Changlun Shao, Huarong Huang, Jieyi Jiang, Xun Zhu,Yayue Liu Lan Liu,Yongjun Lu, Mengfeng Li, Yongcheng Lin,and Zhigang She. Cytotoxic Norsesquiterpene Peroxides from the Endophytic Fungus Talaromyces flavus Isolated from the Mangrove Plant Sonneratia apetala. Journal of Natural Products，2011, 74, 1230–1235.
  62. Cai-Huan Huang, Jia-Hui Pan, Bin Chen, Miao Yu, Hong-Bo Huang, Xun Zhu,Yong-Jun Lu, Zhi-Gang She and Yong-Cheng Lin. Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea. Marine Drugs, 2011, 9(5):832-843.
  63. Hongbo Huang, Xiaojun Feng,Ze’en Xiao, Lan Liu, Hanxiang Li, Lin Ma, Yongjun Lu, Jianhua Ju, Zhigang She, and Yongcheng Lin. Azaphilones and p-Terphenyls from the Mangrove Endophytic Fungus Penicillium chermesinum (ZH4-E2) Isolated from the South China Sea. Journal of Natural Products，2011 74, 997–1002.
  64. Huixian Li, Yali Huang,  Jiong Zhang, Jikun Du,  Hongming Tan, Yongjun Lu, Shining Zhou. Identification and characterization of a novel methionine c-lyase gene from deep-sea sediment metagenomic library. World J Microbiol Biotechnol, 2011, 27:2729–2736. 
  65. Jikun Du, Kai Xiao,  Yali Huang,  Huixian Li, Hongming Tan, Lixiang Cao, Yongjun Lu ,Shining Zhou. Seasonal and spatial diversity of microbial communities in marine sediments of the South China Sea. Antonie van Leeuwenhoek, 2011,100（3）：317-331.
  66. Fenju Lai, Rentian Wu, Jiafeng Wang, Chunming Li, Lan Zou, Yongjun Lu and Chun Liang. Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast. FEMS Yeast Research,2011 Feb;11(1):72-9. 
  67. Lijuan Ma, Yuanliang Zhai, Daorong Feng, Tsz-choi Chan, Yongjun Lu, Xinrong Fu, Jiafeng Wang, Yanhong Chen, Jianna Li, Ke Xu, and Chun Liang. Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Phenotypic Screen in Saccharomyces cerevisiae. Cell Cycle, 2010,9(21):4399-4410.
  68. Hong-Bo Huang, Xiao-Jun Feng, Lan Liu, Bin Chen, Yong-Jun Lu, Lin Ma, Zhi-Gang She, Yong-Cheng Lin. Three Dimeric Naphtho-γ-Pyrones from the Mangrove Endophytic Fungus Aspergillus tubingensis Isolated from Pongamia pinnata. Planta Medica, 2010,76: 1888–1891
  69. Kai-Kai Li, Yong-Jun Lu, Xiao-Hong Song, Zhi-Gang She, Xi-Wei Wu, Lin-Kun An,Chuang-Xing Ye, Yong-Cheng Lin. The metabolites of mangrove endophytic fungus Zh6-B1 from the South China Sea. Bioorganic & Medicinal Chemistry Letters, 2010,20: 3326–3328.
  70. Xiang-hui Li, Yong-lun Zeng, Ye Gao, Xiao-cong Zheng, Qin-fen Zhang, Shi-ning Zhou, Yong-jun Lu*. The ClpP protease homologue is required for the transmission traits and cell division of the pathogen Legionella pneumophila. BMC Microbiology, 2010, 10(1):54.
  71. Zhen Xu, Xue Cheng, Jiafeng Wang, Yuanliang Zhai, Yongjun Lu and Chun Liang. ATP-Dependent Pre-Replicative ComplexAssembly Is Facilitated by Adk1p in Budding Yeast. J. Biological Chemistry, 2010 ,285(39):29974-80.
  72. Jiafeng Wang, Rentian Wu, Yongjun Lu and Chun Liang. Ctf4p Facilitates Mcm10p to Promote Initiation of DNA Replication in Budding Yeast. Biochemical and Biophysical Research Communications, 2010, 395:336–341.
  73. Chun-ling Xu, Jia-feng Wang, Ye Gao, Huang-yu Lin, Lin Du, Shan-shan Yang, Si-mei Long, Zhi-gang She, Xiao-ling Cai, Shi-ning Zhou, Yong-jun Lu*. The anthracenedione compound bostrycin induces mitochondria-mediated apoptosis in the yeast Saccharomyces cerevisiae. FEMS Yeast Research,2010, 10（3）: 297–308.
  74. Yiguang Chen, Jiahui Pan, Fan Liu, JianXiang Yang, Caihuan Huang, Xiaolin Cai, Yongjun Lu, Zhigang She and Yongcheng Lin. A new indene derivative from the marine fungus Phomopsis sp. (No. GX7-4A). Chem Nat Commpd. 2010,2:1-2.
  75. Wen-han Zhu, Lan Luo, Jia-yi Wang, Xiao-hong Zhuang, Ling Zhong, Kang Liao, Yan Zeng, Yong-jun Lu* . Complete nucleotide sequence of pCTX-M360, an intermediate plasmid between pEL60 and pCTX-M3, from a multidrug resistant Klebsiella pneumoniae isolated in China.  Antimicrobial Agents and Chemotherapy, 2009, 53(12):5291-5293 
  76. Ming-jia Yu, Jun Ren, Yong-lun Zeng, Shi-ning Zhou and Yong-jun Lu*. The Legionella pneumophila Dps homolog is regulated by iron and involved in multiple stress tolerance. Journal of Basic Microbiology，2009, 49: 1–8.

二、    主编教材：《生物技术综合实验》, 2017，中山大学出版社，第1版；2019年第二次印刷。