性别:男
工作电话:020-39336580
电子邮件: [email protected]
职称: 副教授
导师类型: 博士生导师
学历: 博士
学科方向
071010-生物化学与分子生物学
0860-生物与医药
研究方向
1. 分子肿瘤：肿瘤发生机制
2. 神经生物学：神经性疾病致病基因的克隆与致病分子机理
个人经历
1992年获华中理工大学（现名华中科技大学）学士学位，2000年毕业于中国科学院上海脑研究所（现名中国科学院上海神经所），2000-2002年纽约大学医学院博士后，2002-2006年哈佛大学医学院麻省总医院和波士顿儿童医院博士后，2006年10月中山大学“百人计划”引进人才进入赌博app 。
讲授课程
遗传学，细胞工程，RNA生物学
论文专著
近期发表文章(*为通讯作者，#为并列第一作者)
1. Xiao, L.#, Li, X.#, Mu, M., Zhou, J., Zhou, P., Xie, X. and Jiang, S.*, (2020) FTO inhibition enhances the anti-tumor affect of temozolomide by targeting MYC-miR-155/23a cluster-MXI1 feedback circuit in glioma. Cancer Res 80 (18) 3945-3958.
2. Xiao, L., Peng, Z., Zhu, A., Xue, R., Lu, R., Mi, J., Xi, S., Chen, W. and Jiang, S.*, (2020) Inhibition of RUNX1 Promotes Cisplatin-induced Apoptosis in Ovarian Cancer Cells. Biochem Pharmacol 180:114116.
3. Chen, W., Du, J., Li, X., Zhi, Z. and Jiang, S.*, (2020) microRNA-137 downregulates MCL1 in ovarian cancer cells and mediates cisplatin-induced apoptosis. Pharmacogenomics, 21, 195-207.
4. Su, J., Ruan, S., Dai, S., Mi, J., Chen, W. and Jiang, S.*, (2019) NF1 regulates apoptosis in ovarian cancer cells by targeting MCL1 via miR-142-5p. Pharmacogenomics, 20, 155-165.
5. Li, X.#, Chen, W. #, Jin, Y. #, Xue, R., Su, J., Mu, Z., Li, J. and Jiang, S.* (2019) miR-142-5p enhances cisplatin-induced apoptosis in ovarian cancer cells by targeting multiple anti-apoptotic genes. Biochem Pharmacol, 161, 98-112. 入选2020年ESI前1%高被引论文
7. Li, X., Jin, Y., Mu, Z., Chen, W. and Jiang, S.*, (2017) MicroRNA-146a-5p enhances cisplatininduced apoptosis in ovarian cancer cells by targeting multiple antiapoptotic genes. Int J Oncol, 51, 327-335.
8. Li, X., Chen, W., Zeng, W., Wan, C., Duan, S. and Jiang, S.*, (2017) microRNA-137 promotes apoptosis in ovarian cancer cells via the regulation of XIAP. Brit J Cancer, 116, 66-76. 入选2018年ESI前1%高被引论文
9. Chen, W., Du, J., Li, X., Su, J., Huang, Y., Ding, N., Zhang, M. and Jiang, S.*, (2017) miR-509-3p promotes cisplatin-induced apoptosis in ovarian cancer cells through the regulation of anti-apoptotic genes. Pharmacogenomics, 18, 1671-1682.
10. Chen, W., Lu, N., Ding, Y., Wang, Y., Chan, L.T., Wang, X., Gao, X., Jiang, S. and Liu, K.* (2017) Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion. eNeuro, 3(6), e0358.
11. Li, S., Yang, C., Zhang, L., Gao, X., Wang, X., Liu, W., Wang, Y., Jiang, S., Wong YH, Zhang Y, Liu K*, (2016) Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling. Proc Natl Acad Sci U S A, 113, 1937-1942.
12. Chen, W., Zeng, W., Li, X., Xiong, W., Zhang, M., Huang, Y., Zhou, L. and Jiang, S.*, (2016) MicroRNA-509-3p increases the sensitivity of epithelial ovarian cancer cells to cisplatin-induced apoptosis. Pharmacogenomics, 17, 187-197.
13. Chen, W., Huang, L., Hao, C., Zeng, W., Luo, X., Li, X., Zhou, L., Jiang, S., Chen, Z.*, and He, Y.*, (2016) MicroRNA-155 promotes apoptosis in SKOV3, A2780, and primary cultured ovarian cancer cells. Tumour Biol, 37, 9289-9299.
14. Xie, C., Chen, W., Zhang, M., Cai, Q., Xu, W., Li, X. and Jiang, S.*, (2015) MDM4 regulation by the let-7 miRNA family in the DNA damage response of glioma cells. FEBS letters, 589, 1958-1965.
15. Shi, Y.#, Liu, Y.#, Wei, Z., Zhang, Y., Zhang, L., Jiang, S., Xiong, Y., Shen, L., He, L., Xing, Q. and Qin S.*, (2015) Hsa-miR-27a is involved in the regulation of CYP3A4 expression in human livers from Chinese Han population. Pharmacogenomics, 16, 1379-1386.
17. Chen, W., Zeng, W., Li, X., Xiong, W., Zhang, M., Huang, Y., Zhou, L.* and Jiang, S.*, (2015) MicroRNA-509-3p increases the sensitivity of epithelial ovarian cancer cells to cisplatin-induced apoptosis. Pharmacogenomics, 17, 187-197.
18. Zhao, J.Y.#, Qiao, B.#, Duan, W.Y.#, Gong, X.H., Peng, Q.Q., Jiang, S.S., Lu, C.Q., Chen, Y.J., Shen, H.B., Huang, G.Y. *, Jin L.* and Wang H.Y.*, (2014) Genetic variants reducing MTR gene expression increase the risk of congenital heart disease in Han Chinese populations. Eur Heart J, 35, 733-742.
19. Wei, Z.#, Jiang, S.#, Zhang, Y., Wang, X., Peng, X., Meng, C., Liu, Y., Wang, H., Guo, L., Qin, S., Zhang J., He L., Zhang L.* and Xing Q.*, (2014) The effect of microRNAs in the regulation of human CYP3A4: a systematic study using a mathematical model. Sci Rep, 4, 4283.
20. Zhou, P., Xu, W., Peng, X., Luo, Z., Xing, Q., Chen, X., Hou, C., Liang, W., Zhou, J., Wu, X., Songyang Z. and Jiang, S.*, (2013) Large-scale screens of miRNA-mRNA interactions unveiled that the 3'UTR of a gene is targeted by multiple miRNAs. PLoS One, 8, e68204.
21. Zhou, J., Wang, W., Gao, Z., Peng, X., Chen, X., Chen, W., Xu, W., Xu, H., Lin, M.C. and Jiang, S.*, (2013) MicroRNA-155 promotes glioma cell proliferation via the regulation of MXI1. PLoS One, 8, e83055.
22. Xu, W., Liu, M., Peng, X., Zhou, P., Zhou, J., Xu, K., Xu, H.* and Jiang, S.*, (2013) miR-24-3p and miR-27a-3p promote cell proliferation in glioma cells via cooperative regulation of MXI1. Int J Oncol, 42, 757-766.
23. Lin, L., Chen, X., Peng, X., Zhou, J., Kung, H.F., Lin, M.C. and Jiang, S.*, (2013) MicroRNA-128 promotes cell-cell adhesion in U87 glioma cells via regulation of EphB2. Oncol Rep, 30, 1239-1248.
24. Li, X., Liu, X., Xu, W., Zhou, P., Gao, P., Jiang, S.*, Lobie, P.E.* and Zhu, T.*, (2013) c-MYC-regulated miR-23a/24-2/27a cluster promotes mammary carcinoma cell invasion and hepatic metastasis by targeting Sprouty2. J Biol Chem, 288, 18121-18133.
25. Xia, H., Cheung, W.K., Ng, S.S., Jiang, X., Jiang, S., Sze, J., Leung, G.K., Lu, G., Chan, D.T., Bian, X.W. Kung H.F., Poon W.S. and Lin M.C., (2012) Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells. J Biol Chem, 287, 9962-9971.
28. Shen, X., Fang, J., Lv, X., Pei, Z., Wang, Y., Jiang, S.*, and Ding, K.*, (2011) Heparin impairs angiogenesis through inhibition of microRNA-10b. J Biol Chem, 286, 26616-26627.
