性别:女
职称: 副教授
学历:博士
电子邮件: [email protected]
导师类型:博士生导师
学科方向:071009-细胞生物学
0860-生物与医药

 

研究方向

1. 细胞衰老与癌变的机制研究
2. 基因组稳定与细胞命运调控机制研究
3. 炎症与衰老的关系研究

 
个人经历

博士毕业于清华大学，随后任职于中山大学

 

讲授课程

本科生课程《遗传学实验》《遗传学》
研究生课程《实验设计与统计分析》

 

学术成就

主要以细胞为研究对象，围绕DNA损伤修复、端粒稳定性维持等方面研究细胞衰老的分子机制。曾在Nucleic Acids Research、Protein Cell、Cell Death Differentiation等国际知名期刊发表研究论文十余篇。

 

承担课题

主持国家自然科学基金面上项目、青年科学基金、横向项目等若干项目。

 

论文专著

  1. Li X, Li X, Xie C, Cai S, Li M, Jin H, Wu S, Cui J, Liu H*, Zhao Y. cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence. Protein Cell. 2022 Jan;13(1):47-64. 
  2. Nie X#, Xiao D#, Ge Y, Xie Y, Zhou H, Zheng T, Li X, Liu H*, Huang H*, Zhao Y*. TRF2 recruits nucleolar protein TCOF1 to coordinate telomere transcription and replication. Cell Death Differ. 2021 Mar;28(3):1062-1075. 

  3. Liu H, Yang Y, Ge Y, Liu J, Zhao Y. TERC promotes cellular inflammatory response independent of telomerase. Nucleic Acids Res. 2019 Sep 5;47(15):8084-8095

  4. Zhang Z, Zhang T, Ge Y, Tang M, Ma W, Zhang Q, Gong S, Wright WE, Shay J, Liu H*, Zhao Y*.2D gel electrophoresis reveals dynamics of t-loop formation during the cell cycle and t-loop in maintenance regulated by heterochromatin state. J Biol Chem. 2019 Apr 19;294(16):6645-6656.

  5. Liu H, Xie Y, Zhang Z, Mao P, Liu J, Ma W, Zhao Y.Telomeric Recombination Induced by DNA Damage Results in Telomere Extension and Length Heterogeneity. Neoplasia. 2018 Sep;20(9):905-916.

  6. Liu H, Liu Q, Ge Y, Zhao Q, Zheng X, Zhao Y. hTERT promotes cell adhesion and migration independent of telomerase activity. Sci Rep. 2016 Mar 14;6:22886.
  7. Liu H, Yuan Y, Guo H, Mitchelson K, Zhang K, et al. Hepatitis B virus encoded x protein suppresses apoptosis by inhibition of the caspase-independent pathway. J Proteome Res 2012 Oct 5;11(10):4803-13.
  8. Guo H*, Liu H*, Mitchelson K, Rao H, Luo M, et al. MicroRNAs-372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B. Hepatology 2011 Sep 2;54:808-819.
  9. Xu Y*, Liu H*, Li F, Sun N, Ren Y, et al. A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform. J Affect Disord 2010 Dec;127(1-3):332-6.
  10. Zhang T, Zhang Z, Li F, Hu Q, Liu H, Tang M, Ma W, Huang J, Songyang Z, Rong Y, Zhang S3, Chen BP, Zhao Y. Looping-out Mechanism for Resolution of Replicative Stress at Telomeres. EMBO Rep. 2017 Aug;18(8):1412-1428.
  11. Zheng XH, Nie X, Fang Y, Zhang Z, Xiao Y, Mao Z, Liu H, Ren J, Wang F, Xia L, Huang J, Zhao Y. A Cisplatin Derivative Tetra-Pt(bpy) as an Oncotherapeutic Agent for Targeting ALT Cancer. J Natl Cancer Inst. 2017 Oct 1;109(10).
  12. Mao P, Liu J, Zhang Z, Zhang H, Liu H, Gao S, Rong YS, Zhao Y. Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells. Nat Commun. 2016 Jul 11;7:12154.
  13. Ge Y, Wu S, Xue Y, Tao J, Li F, Chen Y, Liu H, Ma W, Huang J, Zhao Y. Preferential extension of short telomeres induced by low extracellular pH.Nucleic Acids Res. 2016 Sep 30;44(17):8086-96.
  14. Zheng X, Nie X, Liu H, Fang Y, Zhao Y, Xia L. TMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses. Sci Rep. 2016 May 25;6:26592.
  15. Chen Y, Deng Zh, Jiang Sh, Hu Q, Liu H, Songyang Zh, Ma W, Chen Sh , Zhao Y. Human Cells Lacking Coilin and Cajal Bodies are Proficient in Telomerase Assembly, Trafficking, and Telomere Maintenance. Nucl Acids Res. 2015 Jan 9;43(1):385-95.
  16. Wu Sh, Ge Y, Huang L, Liu H, Xue Y, Zhao Y. BRG1, the ATPase Subunit of SWI/SNF Chromatin Remodeling Complex, Interacts with HDAC2 to Modulate Telomerase Expression in Human Cancer Cells. Cell Cycle 2014 Sep 15;13(18):2869-78.